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ABAMUNE  ABAVIR  ABEC  VIROL 
 
Mechanism of Action
Abacavir is converted to the active form carbovir triphosphate intracellularly. It competitively inhibits the reverse transcriptase of retroviruses interfering with HIV viral RNA-dependent DNA polymerase resulting in inhibition of viral replication.



Indication & Dosage
 
 
Oral
HIV INFECTION COMBINED WITH OTHER ANTIRETROVIRALS
Child: >3 mth: 8 mg/kg bid. Max dose: 600 mg daily.
 
Oral
HIV INFECTION COMBINED WITH OTHER ANTIRETROVIRALS
Adult: 300 mg bid or 600 mg once daily.
  
AdministrationMay be taken with or without food.
  
PrecautionsRenal or mild liver impairment; risk for liver impairment. Discontinued when hepatomegaly and unexplained metabolic acidosis develops, or liver function deteriorates. May impair ability to drive or engage in tasks requiring alertness. Discontinue treatment as soon as hypersensitivity is suspected.
  
Potentially Life-threatening 
Adverse Drug Reactions
Anorexia, headache, nausea, vomiting, diarrhoea, rash, fever, cough, dyspnoea, fatigue, malaise, lethargy, abdominal pain. Pancreatitis and elevated blood glucose and TG concentrations.
  
Adverse Drug Reactions Severe hypersensitivity reactions.
  
InteractionsAlcohol may cause decreased elimination of abacavir. Lactic acidosis with nucleoside analogues concomitantly. Decreased serum concentrations of methadone.
  
   
 

 

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