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Frequently Asked Questions(FAQS)
 
 
Mechanism of Action
Acarbose competitively and reversibly inhibits pancreatic α-amylase and intestinal brush border α-glucosidases, resulting in retardation of glucose absorption from hydrolysed complex carbohydrates and reduction of blood-glucose concentrations.



Indication & Dosage
 
 
Oral
TYPE 2 DM
Adult: Initially, 25 or 50 mg daily increased to tid. May increase dose to 100 mg tid if necessary after 6-8 wk. Max: 200 mg tid.
  
AdministrationShould be taken with food. (Take w/ 1st bite of each main meal.)
  
PrecautionsMonitor LFT every 3 mth for 1st yr and periodically thereafter especially for doses >50 mg tid. Reduce dose or withdraw therapy if transaminases elevations persist. If hypoglycaemia occurs, give glucose orally as a 1st aid measure. Adhere strictly to the prescribed diabetic diet to avoid intensification of GI symptoms.
  
Potentially Life-threatening 
Adverse Drug Reactions
Flatulence, abdominal pain, distension, diarrhoea, nausea, vomiting. Elevation of transaminases, hepatitis, jaundice. Rarely, skin reactions.
  
Adverse Drug Reactions Hepatotoxicity
  
InteractionsDrugs that may increase blood glucose levels e.g. thiazides, steroids, chlorpromazine, atypical antipsychotics, may antagonise the action of acarbose. GI adsorbents and digestive enzyme preparations may reduce acarbose effects; avoid concomitant admin. Cholestyramine may enhance effects of acarbose. Effects of other hypoglycaemics may be potentiated by acarbose. Neomycin may enhance reduction of postprandial blood-glucose and intensify GI symptoms. Acarbose may reduce digoxin bioavailability. May interact with warfarin and affect INR. Increased risk of hypoglycaemia with disopyramide.
  
   
 

 

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