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Mechanism of Action
Aceclofenac, a phenylacetic acid derivative, has antiinflammatory and analgesic properties. It is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins.



Indication & Dosage
 
 
Oral
RHEUMATOID ARTHRITIS
Adult: 100 mg bid.
 
Oral
ANKYLOSING SPONDYLITIS
Adult: 100 mg bid.
 
Oral
OSTEOARTHRITIS
Adult: 100 mg bid.
  
AdministrationShould be taken with food. (Take w/ or immediately after meals.)
  
PrecautionsCautiously administer to patients with GI disease, ulcerative colitis, Crohn's disease, haematological abnormalities, hepatic porphyria; history of bronchial asthma; history of heart failure or hypertension; mild renal, hepatic or cardiac impairment. May impair ability to drive or operate machinery. Elderly.
  
Potentially Life-threatening 
Adverse Drug Reactions
Diarrhoea, nausea, dyspepsia, abdominal pain, dizziness, rashes; increased LFTs.
  
Adverse Drug Reactions Severe GI bleeding; nephrotoxicity; blood dyscrasias.
  
InteractionsMay increase plasma concentrations of lithium and digoxin. Increased nephrotoxicity when used with diuretics or ciclosporin. Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors. May enhance activity of anticoagulants. May increase risk of methotrexate toxicity when administered within 24 hr of methotrexate admin. Increased risk of GI bleed with other NSAIDs. Increased risk of convulsion with quinolones.
  
   
 

 

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