Indication & Dosage |
| |
| |
| Oral |
| RHEUMATOID ARTHRITIS |
| Adult:
100 mg bid. |
| |
| Oral |
| ANKYLOSING SPONDYLITIS |
| Adult:
100 mg bid. |
| |
| Oral |
| OSTEOARTHRITIS |
| Adult:
100 mg bid. |
|
| |
|
| Administration |
Should be taken with food. (Take w/ or immediately after meals.) |
| |
|
| Precautions |
Cautiously administer to patients with GI disease, ulcerative colitis, Crohn's disease, haematological abnormalities, hepatic porphyria; history of bronchial asthma; history of heart failure or hypertension; mild renal, hepatic or cardiac impairment. May impair ability to drive or operate machinery. Elderly. |
| |
|
Potentially Life-threatening
Adverse Drug Reactions |
Diarrhoea, nausea, dyspepsia, abdominal pain, dizziness, rashes; increased LFTs. |
| |
|
| Adverse Drug Reactions |
Severe GI bleeding; nephrotoxicity; blood dyscrasias. |
| |
|
| Interactions |
May increase plasma concentrations of lithium and digoxin. Increased nephrotoxicity when used with diuretics or ciclosporin. Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors. May enhance activity of anticoagulants. May increase risk of methotrexate toxicity when administered within 24 hr of methotrexate admin. Increased risk of GI bleed with other NSAIDs. Increased risk of convulsion with quinolones. |
| |
|
