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Mechanism of Action
Acenocoumarol inhibits synthesis of vit K-dependent coagulation factors VII, IX, X and II including anticoagulant protein C and its cofactor proteins.



Indication & Dosage
 
 
Oral
MANAGEMENT OF THROMBOEMBOLIC DISORDERS
Adult: 8-12 mg on the 1st day and 4-8 mg on the 2nd day. Maintenance: 1-8 mg daily given in a single dose at the same time everyday
  
PrecautionsBleeding disorders; peptic ulcers; severe wounds; cerebrovascular disorders, bacterial endocarditis; renal or hepatic impairment; lactation. Avoid alcohol.
  
Potentially Life-threatening 
Adverse Drug Reactions
Alopecia; fever, nausea, vomiting, diarrhoea; skin rash; cholestatic liver damage.
  
Adverse Drug Reactions Haemorrhage.
  
InteractionsPotentiates hypoglycaemic agents. Bismuth carbonate and Mg reduce absorption. Cimetidine, allopurinol, diuretics and other oral anticoagulants enhance effect. vit K reverses effect.
  
   
 

 

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