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ACERET  ACETEC  SORID 
 
Mechanism of Action
Acitretin is an active metabolite of etretinate but its mechanism of action is unknown.



Indication & Dosage
 
 
Oral
CONGENITAL ICTHYOSIS
Adult: Initially, 25-30 mg daily for 2-4 wk before dose adjustments are done. Usual range: 25-50 mg daily for further 6-8 wk. Max: 75 mg daily for short periods.
 
Oral
DARIER'S DISEASE
Child: 500 mcg/kg/day. Max dose: 35 mg/day.
 
Oral
DARIER'S DISEASE
Adult: Initially, 10 mg daily for 2-4 wk. Max: 50 mg/day
 
Oral
CONGENITAL ICTHYOSIS
Child: 500 mcg/kg/day. Max: 35 mg daily.
 
Oral
SEVERE LICHEN PLANUS
Adult: Initially, 25-30 mg daily for 2-4 wk before dose adjustments are done. Usual range: 25-50 mg daily for further 6-8 wk. Max: 75 mg daily for short periods.
 
Oral
SEVERE LICHEN PLANUS
Child: 500 mcg/kg/day. Max: 35 mg daily.
 
Oral
SEVERE PSORIASIS
Adult:  Initially, 25-30 mg daily for 2-4 wk before dose adjustments are done. Usual range: 25-50 mg daily for further 6-8 wk. Max: 75 mg daily for short periods.
 
Oral
SEVERE PSORIASIS
Child: 500 mcg/kg/day. Max: 35 mg daily.
  
AdministrationShould be taken with food. (Take w/ main meals or w/ a glass of milk.)
  
PrecautionsFemale patients to avoid alcohol during and 2 mth after treatment. Avoid blood donation during therapy or at least 1-3 yr after stopping therapy. Children. Radiographic treatment for prolonged therapy. Therapy should not last >6 mth. Monitor plasma lipid and glucose levels (especially diabetics) regularly. Monitor LFTs.
  
Potentially Life-threatening 
Adverse Drug Reactions
Dryness of mucous membranes and skin; conjunctivitis, dry sore mouth; ophth disturbances; raised lipid level, pancreatitis; sticky skin, dermatitis. Severe headache; GI disturbances; dermatologic reactions, oedema, paronychia, granulomatous lesions, bullous eruptions; reversible hair thinning and alopoecia; CNS disturbances; sweating; taste disturbance, gingivitis; benign intracranial hypertension; photosensitivity; skeletal hyperostosis; extraosseous calcification; premature epiphyseal closure in child.
  
Adverse Drug Reactions Phototoxicity, jaundice, hepatitis and hepatotoxity.
  
InteractionsConcomitant use with keratolytics or high dose vitamin A. Reduces anticoagulant effect of coumarins e.g. warfarin. Concomitant use of microdised progestin oral contraceptives. Concomitant use of methotrexate can potentiate hepatotoxicty. Concomitant use with tetracycline.
  
   
 

 

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