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Indication & Dosage |
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| Intravenous |
| DIFFERENTIAL DIAGNOSIS OF SUPRAVENTRICULAR TACHYCARDIAS |
| Adult:
Initially, 3 mg by rapid IV inj into a central or large peripheral vein over 2 sec with cardiac monitoring; 6 mg may be given after 1-2 minutes if necessary, then 12 mg after a further 1-2 minutes. Avoid increments if high level AV block occurs at any particular dose. |
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| Intravenous |
| DIFFERENTIAL DIAGNOSIS OF SUPRAVENTRICULAR TACHYCARDIAS |
| Child:
Initially, 50-100 mcg/kg; if necessary, may increase dose by 50-100 mcg/kg increments at 1-2 minute intervals or until arrhythmia is controlled. Max dose: 300 mcg/kg. |
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| Intravenous |
| PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA |
| Adult:
Initially, 3 mg by rapid IV inj into a central or large peripheral vein over 2 sec with cardiac monitoring; 6 mg may be given after 1-2 minutes if necessary, then 12 mg after a further 1-2 minutes. Avoid increments if high level AV block occurs at any particular dose. |
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| Intravenous |
| PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA |
| Child:
140 mcg/kg/min by infusion for 6 min. Inject radionuclide 3 min after infusion. |
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| Intravenous |
| MYOCARDIAL IMAGING |
| Adult:
140 mcg/kg/min by infusion for 6 min. Inject radionuclide 3 min after infusion. |
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| Precautions |
Pregnancy; heart transplant patients; patients on dipyridamole (lower initial dose of adenosine 0.5-1 mg); atrial fibrillation or flutter with accessory pathway (conduction along anomalous pathway may increase). |
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| Adverse Drug Reactions |
Facial flushing, palpitations, chest pain, bradycardia, sweating, hypotension, dyspnoea, choking sensation, headache, lightheadedness, tingling, numbness, neck and back pain, nausea, metallic taste. ECG changes suggestive of rhythm disturbances. |
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| Interactions |
Adenosine effects are potentiated by dipyridamole. Adenosine effects antagonised by methylxanthines like caffeine, theophylline, etc. Concomitant carbamazepine may increase the risk of heart block. |
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