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ADENOCOR  ADENOJECT  CARNOSINE  TACHYBAN 
 
Mechanism of Action
Adenosine acts rapidly to slow down conduction through the AV node via the A1 receptors. It also mediates peripheral and coronary vasodilatation by stimulating the A2 receptors. Extremely short plasma half-life (<10 sec) permits dosage titration during IV use every 1-2 min and causes no concern of cumulative effect through repeated dosing.



Indication & Dosage
 
 
Intravenous
DIFFERENTIAL DIAGNOSIS OF SUPRAVENTRICULAR TACHYCARDIAS
Adult: Initially, 3 mg by rapid IV inj into a central or large peripheral vein over 2 sec with cardiac monitoring; 6 mg may be given after 1-2 minutes if necessary, then 12 mg after a further 1-2 minutes. Avoid increments if high level AV block occurs at any particular dose.
 
Intravenous
DIFFERENTIAL DIAGNOSIS OF SUPRAVENTRICULAR TACHYCARDIAS
Child: Initially, 50-100 mcg/kg; if necessary, may increase dose by 50-100 mcg/kg increments at 1-2 minute intervals or until arrhythmia is controlled. Max dose: 300 mcg/kg.
 
Intravenous
PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA
Adult: Initially, 3 mg by rapid IV inj into a central or large peripheral vein over 2 sec with cardiac monitoring; 6 mg may be given after 1-2 minutes if necessary, then 12 mg after a further 1-2 minutes. Avoid increments if high level AV block occurs at any particular dose.
 
Intravenous
PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA
Child: 140 mcg/kg/min by infusion for 6 min. Inject radionuclide 3 min after infusion.
 
Intravenous
MYOCARDIAL IMAGING
Adult: 140 mcg/kg/min by infusion for 6 min. Inject radionuclide 3 min after infusion.
  
PrecautionsPregnancy; heart transplant patients; patients on dipyridamole (lower initial dose of adenosine 0.5-1 mg); atrial fibrillation or flutter with accessory pathway (conduction along anomalous pathway may increase).
  
Adverse Drug Reactions Facial flushing, palpitations, chest pain, bradycardia, sweating, hypotension, dyspnoea, choking sensation, headache, lightheadedness, tingling, numbness, neck and back pain, nausea, metallic taste. ECG changes suggestive of rhythm disturbances.
  
Interactions

Adenosine effects are potentiated by dipyridamole.

Adenosine effects antagonised by methylxanthines like caffeine, theophylline, etc. Concomitant carbamazepine may increase the risk of heart block.

  
   
 

 

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