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Frequently Asked Questions(FAQS)
 
 
Mechanism of Action
Albendazole exhibits a broad-spectrum anthelmintic activity showing vermicidal, ovicidal and larvicidal actions. It inhibits tubulin polymerization in the parasite and blocks glucose uptake; energy levels are reduced resulting to death of the parasite. Susceptible parasites include hookworm, roundworm, threadworm, whipworm, tapeworm, strongyloides, opisthorchis and hydatid disease (Echinococcus).



Indication & Dosage
 
 
Oral
NEUROCYSTICERCOSIS
Adult: >60 kg: 400 mg bid; <60 kg: 15 mg/kg daily in 2 divided doses for 8-30 days.
Max Dosage:  Adult <60 kg: 800 mg daily.
 
Oral
ASCARIASIS, ENTEROBIASIS, HOOKWORM INFECTIONS OR TRICHURIASIS
Adult: 400 mg as a single dose.
 
Oral
ECHINOCOCCOSIS
Adult: >60 kg: 400 mg bid for 28 days; <60 kg: 15 mg/kg daily in 2 divided doses. Max dose: 800 mg daily. For cystic echinococcosis, up to 3 treatment cycles of 28 days each may be given with 14 treatment-free days in between cycles. For alveolar echinococcosis, treatment cycles of 28 days each with 14 treatment-free days in between. Treatment cycles may need to be continued for mth or yr until complete eradication of parasites.
 
Oral
ASCARIASIS, ENTEROBIASIS, HOOKWORM INFECTIONS OR TRICHURIASIS
Child: ≥2 yr: 400 mg as a single dose; 1-2 yr: 200 mg as a single dose for enterobiasis.
 
Oral
STRONGYLOIDIASIS
Adult: 400 mg once daily or bid for 3 consecutive days, repeated after 3 wk if necessary.
 
Oral
GIARDIASIS
Adult: 400mg daily for 5 days.
 
Oral
GIARDIASIS
Child: 400 mg daily for 5 days.
  
AdministrationShould be taken with food.
  
PrecautionsMonitor blood counts and liver function. Administer within 7 days of start of normal menstruation in women of childbearing age. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Perform liver function tests and blood counts before and every 2 wk during high dose therapy of hydatid disease.
  
Potentially Life-threatening 
Adverse Drug Reactions
GI discomfort, headache, nausea, dizziness, allergic reactions, pruritus, raised liver enzymes, alopecia and dry mouth.
  
Adverse Drug Reactions Bone marrow depression.
  
InteractionsCimetidine increases albendazole metabolism. Serum levels are increased if taken with dexamethasone and praziquantel agent.
  
   
 

 

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