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ALFA CAPS  ALFA D3  ALFABOL  ALFACAL  ALFACIP  ALFACIP PLUS  ALFACIP PLUS 500  ALFARICH  ALFASET  ALPHADOL  CALCIT SG  CALFA-D  GR-ALFA  MINROSET  ONE ALPHA  QTR-ALFA  VITALPHA  ZAXIAL 
 
Mechanism of Action
Alfacalcidol is a precursor of the active calcitriol. It does not require renal hydroxylation but requires 25-hydroxylation in the liver for conversion to calcitriol.



Indication & Dosage
 
 
Oral
RICKETS OR OSTEOMALACIA
Adult: Initially, 1 mcg daily. Maintenance: 0.25-1 mcg daily.
 
Oral
HYPOCALCAEMIA
Child:

Premature infants and neonates: 0.05-0.1 mcg/kg daily; <20 kg: 0.05 mcg/kg daily.
 

Elderly: 0.5 mcg daily.

 
Oral
HYPOCALCAEMIA
Adult: Initially, 1 mcg daily. Maintenance: 0.25-1 mcg daily.
 
Oral
RICKETS OR OSTEOMALACIA
Child:

Premature infants and neonates: 0.05-0.1 mcg/kg daily; <20 kg: 0.05 mcg/kg daily.
 

Elderly: 0.5 mcg daily.

 
Oral
HYPOPHOSPHATAEMIA
Adult: Initially, 1 mcg daily. Maintenance: 0.25-1 mcg daily.
 
Oral
HYPOPHOSPHATAEMIA
Child:

Premature infants and neonates: 0.05-0.1 mcg/kg daily; <20 kg: 0.05 mcg/kg daily.
 

Elderly: 0.5 mcg daily.

 
Oral
RENAL OSTEODYSTROPHY
Adult: Initially, 1 mcg daily. Maintenance: 0.25-1 mcg daily.
 
Oral
RENAL OSTEODYSTROPHY
Child:

Premature infants and neonates: 0.05-0.1 mcg/kg daily; <20 kg: 0.05 mcg/kg daily.
 

Elderly: 0.5 mcg daily.

 
Oral
HYPOPARATHYROIDISM
Adult: Initially, 1 mcg daily. Maintenance: 0.25-1 mcg daily.
 
Oral
HYPOPARATHYROIDISM
Child:

Premature infants and neonates: 0.05-0.1 mcg/kg daily; <20 kg: 0.05 mcg/kg daily.
 

Elderly: 0.5 mcg daily.

  
AdministrationShould be taken with food.
  
PrecautionsPregnancy, lactation, renal impairment, infants, elderly. Monitor serum levels of calcium in patients with renal failure. Caution in hypercalciuria esp in those with history of renal calculi. Avoid in patients with hypersensitivity to inj. containing propylene glycol.
  
Adverse Drug Reactions Anorexia, nausea, vomiting, diarrhoea, lassitude, polyuria, sweating, headache, thirst, vertigo, pruritus, rash, urticaria. Hypercalcaemia, hypercalciuria and ectopic calcification. In case of renal impairment, hyperphosphataemia. In hypercalcaemic dialysis patients, possibility of calcium influx from the dialysate should be considered.
  
InteractionsThiazides may increase the risk of hypercalcaemia. Some antiepileptics e.g. carbamazepine, phenobarbital, phenytoin and primidone may increase vitamin D requirements. Rifampicin, isoniazid and corticosteroids may reduce the efficacy of vitamin D.
  
   
 

 

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