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Indication & Dosage |
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| Oral |
| RICKETS OR OSTEOMALACIA |
| Adult:
Initially, 1 mcg daily. Maintenance: 0.25-1 mcg daily. |
| |
| Oral |
| HYPOCALCAEMIA |
| Child:
Premature infants and neonates: 0.05-0.1 mcg/kg daily; <20 kg: 0.05 mcg/kg daily.
Elderly: 0.5 mcg daily. |
| |
| Oral |
| HYPOCALCAEMIA |
| Adult:
Initially, 1 mcg daily. Maintenance: 0.25-1 mcg daily. |
| |
| Oral |
| RICKETS OR OSTEOMALACIA |
| Child:
Premature infants and neonates: 0.05-0.1 mcg/kg daily; <20 kg: 0.05 mcg/kg daily.
Elderly: 0.5 mcg daily. |
| |
| Oral |
| HYPOPHOSPHATAEMIA |
| Adult:
Initially, 1 mcg daily. Maintenance: 0.25-1 mcg daily. |
| |
| Oral |
| HYPOPHOSPHATAEMIA |
| Child:
Premature infants and neonates: 0.05-0.1 mcg/kg daily; <20 kg: 0.05 mcg/kg daily.
Elderly: 0.5 mcg daily. |
| |
| Oral |
| RENAL OSTEODYSTROPHY |
| Adult:
Initially, 1 mcg daily. Maintenance: 0.25-1 mcg daily. |
| |
| Oral |
| RENAL OSTEODYSTROPHY |
| Child:
Premature infants and neonates: 0.05-0.1 mcg/kg daily; <20 kg: 0.05 mcg/kg daily.
Elderly: 0.5 mcg daily. |
| |
| Oral |
| HYPOPARATHYROIDISM |
| Adult:
Initially, 1 mcg daily. Maintenance: 0.25-1 mcg daily. |
| |
| Oral |
| HYPOPARATHYROIDISM |
| Child:
Premature infants and neonates: 0.05-0.1 mcg/kg daily; <20 kg: 0.05 mcg/kg daily.
Elderly: 0.5 mcg daily. |
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| Administration |
Should be taken with food. |
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| Precautions |
Pregnancy, lactation, renal impairment, infants, elderly. Monitor serum levels of calcium in patients with renal failure. Caution in hypercalciuria esp in those with history of renal calculi. Avoid in patients with hypersensitivity to inj. containing propylene glycol. |
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| Adverse Drug Reactions |
Anorexia, nausea, vomiting, diarrhoea, lassitude, polyuria, sweating, headache, thirst, vertigo, pruritus, rash, urticaria. Hypercalcaemia, hypercalciuria and ectopic calcification. In case of renal impairment, hyperphosphataemia. In hypercalcaemic dialysis patients, possibility of calcium influx from the dialysate should be considered. |
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| Interactions |
Thiazides may increase the risk of hypercalcaemia. Some antiepileptics e.g. carbamazepine, phenobarbital, phenytoin and primidone may increase vitamin D requirements. Rifampicin, isoniazid and corticosteroids may reduce the efficacy of vitamin D. |
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