Indication & Dosage |
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| Oral |
| PANIC ATTACKS |
| Adult:
Up to 10 mg daily. |
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| Oral |
| SHORT-TERM TREATMENT OF ANXIETY DISORDERS |
Adult:
Adult: 0.25-0.5 mg tid, increased to 3-4 mg daily if necessary.
Elderly: Initially, 0.25 mg bid/tid. |
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| Administration |
May be taken with or without food. (Side effects such as sleepiness/ drowsiness may be reduced if taken immediately after meals.) |
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| Precautions |
Dosage reduction or gradual withdrawal. Dependence. Geriatric or debilitated patients. Muscle weakness, impaired hepatic or renal function; arteriosclerosis; obesity; depression particularly suicidal tendency; chronic pulmonary insufficiency. May impair performance of tasks that require mental alertness. Childn <18 yrs. |
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Potentially Life-threatening
Adverse Drug Reactions |
Psychological and physical dependence, withdrawal syndrome; drowsiness, sedation, vertigo, headache, visual disturbances, GI disturbances, jaundice; fatigue, muscle weakness, ataxia, dizziness, confusion and depression. |
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| Adverse Drug Reactions |
Occasionally, blood dyscrasias. |
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| Interactions |
Cimetidine and fluoxetine reduce the clearance of alprazolam. Alprazolam enhances activity of imipramine and desipramine. Potentiates action of alcohol and CNS depressants. Reduced conc with cigarette smoking by 50%. |
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