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ALAP  ALEP  ALEP-SR  ALLTOP  ALP  ALPAM  ALPOSE  ALPRA  ALPRADOL-MD  ALPRAQUIL  ALPRAQUIL  ALPRAX  ALPRAX  ALPRAX  ALPRAX-MT  ALPRAZOLAM  ALPROSE  ALRIF  ALZEX  ALZEX  ALZO  ALZOACT  ALZOKAM  ALZOKAM  ALZOLAM  ALZOLAM  ALZOMAX  ALZOPAX-XR  ALZOT  ANAX  ANXICALM  ANXICO  ANXIT  ANXIT  ANXOREL  ANXYL  ANZILUM  ATAM  ATREST  BALMUSA  BALMUSA-D  BESQUIL  BIO ZOLAM  BLIZ MD  F.A.D  F.A.D  FINEZOL  JOLISTAR  KAPROLAM  L-PEEZ  LORAL  LORAL  LUZARN  MANOREST  MORECALM  NITRIL  PACYL  PACYL  PIZOLAM  PLAXID  PRALAM  PROCALM  QUIET  RESTYL  RIAN  RUNREST  SALIREST  SELAMB  SOMNIA 0.25  SOMNIA 0.50  SOWEL  SUKOON  TAGAT  TENSYL  TENZOLE  TENZOLE-SR  TRANAX  TRANAX  TRIKA  TRIKA  VISRAM  WELNORM  WYCALM  WYCALM FORT  XANTI  XANTI XR  ZALLPAM  ZAM  ZAMITOL  ZAMITOL-SR  ZEFTRA  ZENAX  ZOCAM  ZOLAM  ZOLAM  ZOLAX  ZOLAX  ZOLDAC  ZOLDAC  ZOLIPAX  ZOLIPAX  ZOLIPAX SR  ZOLIPAX SR  ZOLIPAX SR  ZOLOID  ZOMARK  ZOPAX  ZOPAX  ZOPIC  ZOREST  ZOTAM  ZOTAM 
 
Mechanism of Action
Alprazolam has anxiolytic, muscle-relaxant, anticonvulsant, antidepressant and sleep-modifying effects. It binds to the g aminobutyric acid (GABA)-specific sites throughout the CNS, leading to an increase in the inhibitory effect of GABA on neuronal excitability. Increased neuronal permeability to chloride ions thus results in hyperpolarisation and stabilisation.



Indication & Dosage
 
 
Oral
PANIC ATTACKS
Adult: Up to 10 mg daily.
 
Oral
SHORT-TERM TREATMENT OF ANXIETY DISORDERS
Adult: Adult: 0.25-0.5 mg tid, increased to 3-4 mg daily if necessary.
Elderly: Initially, 0.25 mg bid/tid.
  
AdministrationMay be taken with or without food. (Side effects such as sleepiness/ drowsiness may be reduced if taken immediately after meals.)
  
PrecautionsDosage reduction or gradual withdrawal. Dependence. Geriatric or debilitated patients. Muscle weakness, impaired hepatic or renal function; arteriosclerosis; obesity; depression particularly suicidal tendency; chronic pulmonary insufficiency. May impair performance of tasks that require mental alertness. Childn <18 yrs.
  
Potentially Life-threatening 
Adverse Drug Reactions
Psychological and physical dependence, withdrawal syndrome; drowsiness, sedation, vertigo, headache, visual disturbances, GI disturbances, jaundice; fatigue, muscle weakness, ataxia, dizziness, confusion and depression.
  
Adverse Drug Reactions Occasionally, blood dyscrasias.
  
Interactions

Cimetidine and fluoxetine reduce the clearance of alprazolam. Alprazolam enhances activity of imipramine and desipramine.

Potentiates action of alcohol and CNS depressants. Reduced conc with cigarette smoking by 50%.

  
   
 

 

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