Indication & Dosage |
| |
| |
| Oral |
| SEVERE GRAM-NEGATIVE INFECTIONS RESISTANT TO GENTAMICIN AND TOBRAMYCIN |
| Adult:
15 mg/kg daily in equally divided doses injected every 8 or 12 hr for 7-10 days. Max dose: Up to 500 mg every 8 hr in life-threatening infections. Max cumulative dose: 15 g. Doses may be given via IM, slow IV inj over 2-3 minutes or IV infusion. |
| |
| Oral |
| UNCOMPLICATED URINARY TRACT INFECTIONS |
| Adult:
250 mg bid, given via IM, IV inj over 2-3 minutes or as IV infusion. |
| |
| Oral |
| SEVERE GRAM-NEGATIVE INFECTIONS RESISTANT TO GENTAMICIN AND TOBRAMYCIN |
| Child:
15 mg/kg daily in equally divided doses injected every 8 or 12 hr for 7-10 days. Neonates: 10 mg/kg daily in 2 divided doses. |
|
| |
|
| Administration |
Renal impairment; vertigo, tinnitus. Discontinue if signs of ototoxicity, neurotoxicity or hypersensitivity occurs; lactation. Safety has not been established for treatment period >14 days. Monitor renal function before and during treatment. |
| |
|
| Precautions |
Ototoxicity, nephrotoxicity, neuromuscular blockade. |
| |
|
| Adverse Drug Reactions |
Tinnitus, vertigo; ataxia and overt deafness. |
| |
|
| Interactions |
Increased ototoxic or nephrotoxic effects with other nephrotoxic or ototoxic drugs. Enhanced neuromuscular blockade with neuromuscular blocking drugs. Increased risk of ototoxicity with potent diuretics. Amphotericin B may lead to increased nephrotoxicity and reduced clearance of amikacin when used together. |
| |
|
