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ACIL  AFCIN  ALKANIT  ALNAMIK  AMIACT  AMIBIOTIC  AMICIN  AMICOM  AMIKACIN  AMIKAS  AMIKATER  AMIKCIN  AMIKEF  AMIKIN  AMIMAC  AMIMAX  AMINOCIN  AMIRON  AMISTAR  AMISTER  AMISULF  AMITAX  AMIVIR  AMIZA  AMK  AMRICIN  AMTOP  AMZO  ANAMIKA  ANTINAG  ATMIKA  AVIKACIN  BEKACIN  BLOCIN  CADICIN  CADICIN  CINAMICA  CINAS  CURESIN  D-CIN  ELMIK  EMCIN  EMICA  EMKA  ENDOCIN  ENDOCIN E/E DROPS  ERKACIN  EROCIN  FYMIKA  GEMKA  GLOMIKA  GLYKACIN  ICIN-500  INKACIN  IVIMICIN  JYOMIK  KACINA  KASINO  KAWACIN  LEMICIN  LEXCIN  LUPAMIK  MALARACIN  MALARACIN  MEGAMICA  MEGAMICA  MICA  MICARE  MIKABIT  MIKACIN  MIKAFINE  MIKAJECT  MIKATAX 100  MIKATAX 250  MIKATAX 500  MKCN  NICIN  NIMICIN  NISKACIN  NOVACIN  ORKACIN  OSIN  PROCIN  SAK  SANMICA  SIMCA  SIOMIK  SPAIKE  STARKACIN  STARMIK  STARMIK 500  TAURKACIN  TICIN INJ  TRAKACIN  ZENCIN  ZOMIKA 
 
Mechanism of Action
Amikacin binds to 30S ribosomal subunits of susceptible bacteria, thus inhibiting its protein synthesis.



Indication & Dosage
 
 
Oral
SEVERE GRAM-NEGATIVE INFECTIONS RESISTANT TO GENTAMICIN AND TOBRAMYCIN
Adult: 15 mg/kg daily in equally divided doses injected every 8 or 12 hr for 7-10 days. Max dose: Up to 500 mg every 8 hr in life-threatening infections. Max cumulative dose: 15 g. Doses may be given via IM, slow IV inj over 2-3 minutes or IV infusion.
 
Oral
UNCOMPLICATED URINARY TRACT INFECTIONS
Adult: 250 mg bid, given via IM, IV inj over 2-3 minutes or as IV infusion.
 
Oral
SEVERE GRAM-NEGATIVE INFECTIONS RESISTANT TO GENTAMICIN AND TOBRAMYCIN
Child: 15 mg/kg daily in equally divided doses injected every 8 or 12 hr for 7-10 days. Neonates: 10 mg/kg daily in 2 divided doses.
  
AdministrationRenal impairment; vertigo, tinnitus. Discontinue if signs of ototoxicity, neurotoxicity or hypersensitivity occurs; lactation. Safety has not been established for treatment period >14 days. Monitor renal function before and during treatment.
  
PrecautionsOtotoxicity, nephrotoxicity, neuromuscular blockade.
  
Adverse Drug Reactions Tinnitus, vertigo; ataxia and overt deafness.
  
Interactions

Increased ototoxic or nephrotoxic effects with other nephrotoxic or ototoxic drugs. Enhanced neuromuscular blockade with neuromuscular blocking drugs. Increased risk of ototoxicity with potent diuretics.

Amphotericin B may lead to increased nephrotoxicity and reduced clearance of amikacin when used together.

  
   
 

 

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