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Indication & Dosage |
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| Oral |
| NEUROPATHIC PAIN |
| Adult:
Initially, 50-75 mg daily in divided doses or as a single dose at night, increased gradually, if necessary to 150 mg daily. In severe cases, doses up to 200-300 mg daily have been used. |
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| Oral |
| MIGRAINE PROPHYLAXIS |
| Adult:
Initially, 50-75 mg daily in divided doses or as a single dose at night, increased gradually, if necessary to 150 mg daily. In severe cases, doses up to 200-300 mg daily have been used. |
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| Oral |
| NOCTURNAL ENURESIS |
| Child:
>11 yr: 25-50 mg at bedtime; 6-10 yr: 10-20 mg at bedtime. Treatment should not continue >3 mth. |
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| Oral |
| DEPRESSION |
| Adult:
Initially, 50-75 mg daily in divided doses or as a single dose at night. May increase dose gradually to 150 mg daily, if needed. Up to 300 mg daily may be used in severe cases. |
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| Oral |
| DEPRESSION |
| Child:
Adolescents(>16yr): 30-75 mg daily or in divided doses, preferably at bedtime.
Elderly: 30-75 mg daily or in divided doses, preferably at bedtime. |
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| Administration |
May be taken with or without food. |
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| Precautions |
Bipolar illness, recovery after MI, pregnancy, elderly, CVS disease, liver impairment, epilepsy, psychosis, avoid alcohol; abrupt withdrawal; urinary retention, prostatic hyperplasia; chronic constipation; angle-closure glaucoma; phaeochromocytoma. Monitor for signs of clinical worsening. |
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Potentially Life-threatening
Adverse Drug Reactions |
Postural hypotension, tachycardia, conduction disturbances. Dry mouth, wt gain, sour or metallic taste, stomatitis, constipation; blurring of vision, urinary retention, fatigue, dizziness, weakness, tremors, headache, confusion and delirium in elderly, wt gain, sexual disturbances; peripheral neuropathy; urticaria, angioedema, sweating. |
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| Adverse Drug Reactions |
Cardiac arrhythmias. |
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| Interactions |
Potentiates sedative effect of alcohol; antiparkinson agents and antipsychotic drugs increase risk of anticholinergic effects. Reduced effect of antihypertensives. Marked hyperpyrexia, convulsions and coma with MAOIs. Potentiates hypertensive effects of sympathomimetics. |
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