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Indication & Dosage |
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| Oral |
| TREATMENT OF DEPRESSION |
Adult:
Initially, 50 mg bid-tid, increased gradually up to 100 mg tid. For severely depressed patients in the hospital: Up to 300 mg daily.
Elderly: Initially, 25 mg bid-tid increased as necessary after 5-7 days up to 150 mg daily. |
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| Administration |
May be taken with or without food. |
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| Precautions |
Recovery after MI, elderly, CVS disease, liver impairment, epilepsy, psychosis, increased intraocular pressure, history of urinary retention, alcohol, pregnancy and lactation; avoid abrupt withdrawal. |
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Potentially Life-threatening
Adverse Drug Reactions |
Postural hypotension, tachycardia, conduction disturbances; dry mouth, blurring of vision, constipation, urinary retention, fatigue, dizziness, weakness, tremors, headache, confusion and delirium in elderly, weight gain, tardive dyskinesia; neuroleptic malignant syndrome; sexual disturbances. |
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| Adverse Drug Reactions |
Agranulocytosis, thrombocytopenia; cardiac arrhythmias. |
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| Interactions |
Potentiates sedative effect of alcohol. Antiparkinson agents, antipsychotic drugs increase risk of anticholinergic effects. Reduces effect of antihypertensives. Marked hyperpyrexia, convulsions and coma with MAOIs. Potentiates hypertensive effects of sympathomimetics. Reduced serum levels with barbiturates. |
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