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Indication & Dosage |
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| Oral |
| ADJUVANT TREATMENT IN EARLY BREAST CANCER IN POSTMENOPAUSAL WOMEN |
| Adult:
1 mg daily. Adjuvant treatment may be continued for up to 5 yr. |
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| Oral |
| ADVANCED BREAST CANCER IN POSTMENOPAUSAL WOMEN |
| Adult:
1 mg daily. Adjuvant treatment may be continued for up to 5 yr. |
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| Administration |
May be taken with or without food. |
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| Precautions |
Lactation. Moderate or severe hepatic impairment, hyperlipidaemias. Laboratory test for menopause if status is doubtful. Bone mass density test should be conducted at the start of the therapy and at regular intervals thereafter. |
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| Adverse Drug Reactions |
Hot flushes, vaginal dryness, vaginal bleeding, hair thinning, anorexia, nausea, vomiting, diarrhoea, headache, arthralgia, bone fractures, rash, oedema, myalgia, fever, weight gain, leucopenia, flu-like syndrome, asthenia, dizziness, drowsiness, abnormal liver enzyme values, thrombophloebitis, anaphylaxis. |
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| Interactions |
Efficacy decreased by oestrogens. Plasma concentrations decreased by tamoxifen. |
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