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Indication & Dosage |
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| Intravenous |
| HAEMORRHAGE |
| Adult:
Admin a test dose of 10,000 KIU at least 10 minutes before starting treatment. Loading dose: 500,000-1,000,000 KIU, given by slow inj or infusion (max rate: 100,000 KIU/minute) with the patient in supine position, may continue with 200,000 KIU/hr until the haemorrhage is controlled. Doses to be given via central venous line. |
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| Intravenous |
| HAEMORRHAGE |
| Child:
1 mth-18 yr: Test dose of 200 KIU/kg, followed after 10 minutes by a dose of 10,000 KIU/kg given over 20 minutes, then continuous infusion of 3,000 KIU/kg/hr until bleeding is controlled. |
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| Intravenous |
| OPEN HEART SURGERY |
| Adult:
Admin a test dose of 10,000 KIU at least 10 minutes before starting treatment. Loading dose: 2,000,000 KIU over 20-30 minutes after induction of anaesthesia but before incision or reopening of wound, followed by continuous infusion of 500,000 KIU/hr until the end of the surgery. Add an additional dose of 2,000,000 KIU into the prime volume of the extracorporeal circuit. Doses to be given via central venous line. For patients with septic endocarditis, add a dose of 3 000 000 KIU into the prime volume of the circuit; may continue infusion into the early postoperative period. Usual total amount ≤7 000 000 KIU. |
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| Precautions |
Neonates and children. Pregnancy and lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Admin through peripheral line may cause local thrombophlebitis, bronchospasm, GI disturbances. Hypersensitivity or pseudo-allergic reactions may occur after 1st dose or thereafter eg, skin rashes and eruptions, tachycardia, pallor or cyanosis, dyspnoea, nausea and anaphylactic shock. |
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| Adverse Drug Reactions |
Fatal anaphylactic reactions.Fatal anaphylactic reactions.Fatal anaphylactic reactions. |
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| Interactions |
Co-admin with heparin may prolong activated blood clotting time, but dosage of heparin need not be adjusted until risk of thromboses associated with use of aprotinin for surgery has been determined. May block acute response of BP to captopril. |
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