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Indication & Dosage |
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| Oral |
| ACUTE MANIC EPISODES OF BIPOLAR DISORDER |
| Adult:
30 mg once daily, decreased to 15 mg once daily based on tolerability. |
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| Oral |
| SCHIZOPHRENIA |
| Adult:
Initial dose: 10 or 15 mg/day. Usual maintenance dose: 15mg once daily. Adjust dose at intervals of at least 2 wk. Max dose: 30 mg daily. |
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| Administration |
May be taken with or without food. |
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| Precautions |
Patients with known CV diseases (e.g. history of MI, IHD, CCF or conduction abnormalities), cerebrovascular diseases or conditions which would predispose patients to hypotension; Alzheimer's disease and dementia. Caution when operating hazardous machinery, including automobiles when taking aripiprazole. Pregnancy. |
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| Adverse Drug Reactions |
Headache, agitation, insomnia, somnolence; dyspepsia, constipation, pain, nausea, vomiting; asthaenia, dizziness, abdominal pain; dry mouth; anxiety, akathisia; orthostatic hypotension; hypertonia, tremor and blurred vision. |
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| Interactions |
Drugs that induce CYP3A4 (e.g. carbamazepine) could cause an increase in aripiprazole clearance and lower blood levels. Inhibitors of CYP3A4 (e.g. ketoconazole) or CYP2D6 (e.g. quinidine, fluoxetine or paroxetine) can inhibit aripiprazole elimination and cause increased blood levels. Increased CNS depression with ethanol. Ingestion with a high-fat meal delays time to peak plasma level. |
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