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Indication & Dosage |
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| Oral |
| INDUCTION OF REMISSIONS IN ACUTE LYMPHOBLASTIC LEUKAEMIA |
| Child:
As monotherapy: 200 units/kg/day via IV inj for 28 days, to be given over at least 30 min in a running infusion of normal saline or glucose 5%. |
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| Oral |
| INDUCTION OF REMISSIONS IN ACUTE LYMPHOBLASTIC LEUKAEMIA |
| Adult:
1000 units/kg/day via IV inj for 10 days after treatment with vincristine and prednisone or prednisolone. Alternatively, 6000 units/m2 via IM inj, given every 3rd day for 9 doses during treatment with vincristine and prednisone or prednisolone. As monotherapy: 200 units/kg/day via IV inj for 28 days. IV inj to be given over at least 30 min in a running infusion of normal saline or glucose 5%. For IM admin, no more than 2 ml of a solution in normal saline should be injected at a single site. |
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| Precautions |
Should be used after skin testing, in hospital setting. Liver disease, frequently blood count monitoring. Lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Chills, pyrexia, liver disorders. Hyperammonaemia, decrease of fibrinogen and clotting factors, alteration in blood lipids and cholesterol, hypoalbuminaemia, uraemia, renal failure (occasional). Hyperglycaemia. Nausea, vomiting, anorexia, weight loss. CNS disturbances including depression, coma, hallucinations, Parkinson-like syndrome. Marked leucopenia, transient bone-marrow depression. |
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| Adverse Drug Reactions |
Acute anaphylaxis; fatal hyperthermia; pancreatitis; ketoacidosis. |
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| Interactions |
Activity of methotrexate may be reduced if L-asparaginase is given before hand. |
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