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PENGLOBE 
 



Indication & Dosage
 
 
Oral
PNEUMONIA
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
 
Oral
PNEUMONIA
Adult:  400-800 mg bid-tid.
 
Oral
OTITIS MEDIA
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
 
Oral
OTITIS MEDIA
Adult: 400-800 mg bid-tid.
 
Oral
SEPTICAEMIA
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
 
Oral
SEPTICAEMIA
Adult: 400-800 mg bid-tid.
 
Oral
MENINGITIS
Child:  >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
 
Oral
MENINGITIS
Adult: 400-800 mg bid-tid.
 
Oral
ENDOCARDITIS
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
 
Oral
ENDOCARDITIS
Adult:  400-800 mg bid-tid.
 
Oral
BILIARY TRACT INFECTIONS
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
 
Oral
BILIARY TRACT INFECTIONS
Adult: 400-800 mg bid-tid.
 
Oral
PERITONITIS
Adult: 400-800 mg bid-tid.
 
Oral
PERITONITIS
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
 
Oral
PERINATAL STREPTOCOCCAL INFECTIONS
Adult: 400-800 mg bid-tid.
 
Oral
PERINATAL STREPTOCOCCAL INFECTIONS
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
 
Oral
TYPHOID AND PARATYPHOID FEVER
Adult: 400-800 mg bid-tid.
 
Oral
TYPHOID AND PARATYPHOID FEVER
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
 
Oral
GASTROENTERITIS
Adult: 400-800 mg bid-tid.
 
Oral
GASTROENTERITIS
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
 
Oral
LISTERIOSIS
Adult: 400-800 mg bid-tid.
 
Oral
LISTERIOSIS
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
 
Oral
BRONCHITIS
Adult: 400-800 mg bid-tid.
 
Oral
BRONCHITIS
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
 
Oral
UTI
Adult: 400-800 mg bid-tid.
 
Oral
UTI
Child:  >5 yr: 25-50 mg/kg daily in 2-3 divided doses.
 
Oral
UNCOMPLICATED GONORRHOEA
Adult:
   
Administration May be taken with or without food. (May be taken w/ meals to reduce GI discomfort.)
   
Precautions Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitisation may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route. Discontinue in case of skin rash.
   
Adverse Drug Reactions Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis. Nausea; vomiting; pseudomembranous colitis.
   
Interactions Probenecid prolongs T½ of bacampicillin. Bacteriostatic drugs e.g. chloramphenicol, tetracyclines; other antibacterials; anticoagulants.
   
   
 

 
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