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Indication & Dosage |
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| Oral |
| SEVERE CHRONIC SPASTICITY ASSOCIATED WITH A VARIETY OF CONDITIONS |
| Adult:
Initially, 5 mg tid for 3 days increased to 10 mg tid for 3 days, then in similar increments and intervals until either 20 mg tid is reached or until desired effect is obtained. Max: 100 mg daily. |
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| Oral |
| SEVERE CHRONIC SPASTICITY ASSOCIATED WITH A VARIETY OF CONDITIONS |
| Child:
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| Intrathecal |
| SEVERE CHRONIC SPASTICITY ASSOCIATED WITH A VARIETY OF CONDITIONS |
| Adult:
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| Oral |
| SEVERE CHRONIC SPASTICITY ASSOCIATED WITH A VARIETY OF CONDITIONS |
| Adult:
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| Administration |
Should be taken with food. |
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| Precautions |
Cerebrovascular disorders, epilepsy, severe psychotic disorders, confusional states, history of peptic ulcer, respiratory depression, DM, hepatic or renal impairment, elderly, pregnancy. Avoid sudden withdrawal. |
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Potentially Life-threatening
Adverse Drug Reactions |
Sedation, drowsiness, ataxia, dizziness, headache, confusion, hallucinations, skin reactions, GI symptoms, enuresis. |
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| Adverse Drug Reactions |
Respiratory or CV depression, seizures. |
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| Interactions |
Hypotensive effect may be increased with antihypertensives. Concomitant use with levodopa in Parkinson patients may result in confusion, agitation, hallucinations. |
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