ADVANCED PROSTATE CANCER WITH ORCHIDECTOMY OR GONADORELIN THERAPY
Adult:
To be started 3 days before gonadorelin therapy; 50 mg once daily.
Administration
May be taken with or without food.
Precautions
Monitor liver function regularly in hepatically impaired patients on prolonged therapy. Monitoring serum levels of Prostate Specific Antigen (PSA) may be useful in evaluating the patient's clincial progress.
Adverse Drug Reactions
Nausea, vomiting, diarrhoea, asthenia, gynaecomastia, breast tenderness, hot flushes, pruritus, dry skin, alopecia, hirsutism, decreased libido, impotence, weight gain; less commonly hypersensitivity reactions including angioneurotic oedema and urticaria, interstitial lung disease; rarely abdominal pain, CV disorders (including angina, heart failure and arrhythmias), depression, dyspepsia, haematuria, cholestasis, jaundice, thrombocytopenia.
