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Indication & Dosage |
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| Parenteral |
| SQUAMOUS CELL OR TESTICULAR TUMOURS |
| Adult:
15,000 IU three times a wk or 30,000 IU twice a wk IM/IV, repeated at usual intervals of 3-4 wk up to a total cumulative dose of 500,000 IU.
Elderly: Dose reduction is necessary. |
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| Oral |
| LYMPHOMA |
| Adult:
15,000 IU once or twice a wk, up to a total cumulative dose of 225,000 IU. Elderly: Dose reduction is necessary. |
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| Injection |
| MALIGNANT EFFUSIONS |
| Adult:
60,000 IU in 100 ml of 0.9% sodium chloride instilled into the affected serous cavity, may be repeated up to a total cumulative dose of 500,000 IU.
Elderly: Dose reduction is necessary. |
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| Precautions |
Pulmonary infection, preexisting pulmonary function impairment, renal impairment. Patients who received radiotherapy, particularly to the thorax. Regular chest x-rays should be done. Elderly. Discontinue treatment if chest x-rays show infiltrates or breathlessness occurs. |
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Potentially Life-threatening
Adverse Drug Reactions |
Fever, thrombophloebitis (inj). Acute anaphylactoid reactions, hyperpyrexia. Rash, erythema, pruritus, vesiculation, hyperkeratosis, nail changes, alopecia, hyperpigmentation, striae, stomatitis. |
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| Adverse Drug Reactions |
Pulmonary toxicity, interstitial pneumonitis, fibrosis, cardiorespiratory collapse in patients with lymphoma. |
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| Interactions |
Lomustine increases severity of leukopenia. Elimination decreased by cisplatin. Decreases plasma levels of digoxin and phenytoin. |
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