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Indication & Dosage |
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| Oral |
| SHORT-TERM MANAGEMENT OF ANXIETY DISORDERS |
| Adult:
As hydrochloride: Initially, 5 mg bid/tid increased by 5-mg increments at intervals of 2-3 days. |
| Max Dosage: 45 mg daily in divided doses |
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| Administration |
May be taken with or without food. (Take consistently either always w/ or always without meals.) |
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| Precautions |
Preceding co-administration of MAOIs, decreased hepatic or renal function. In patients on benzodiazepines, withdraw the drug gradually. May impair ability to drive or operate machinery. |
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| Adverse Drug Reactions |
Dizziness, nausea, headache, nervousness, lightheadedness, excitement, paraesthesia, sleep disturbances, chest pain, tinnitus, nasal congestion, sore throat. Less sedation and lower potential for dependence compared to other anxiolytics. |
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| Interactions |
Enhanced sedative effects with alcohol or CNS depressants. Increases serum haloperidol. Concurrent admin with MAO inhibitors may lead to increase in blood pressure. |
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