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Indication & Dosage |
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| Oral |
| NHIBITION OF PHYSIOLOGICAL LACTATION |
| Adult:
1 mg as a single dose on the 1st day postpartum. |
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| Oral |
| SUPPRESSION OF LACTATION |
| Adult:
250 mcg every 12 hr for 2 days |
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| Oral |
| HYPERPROLACTINEMIA-ASSOCIATED DISORDERS |
| Adult:
Initially, 500 mcg/wk then increased at mthly intervals by 500 mcg/wk according to response. Wkly dose may be admin on a single occasion or in 2 divided doses on separate days; doses >1 mg should be given as divided doses. Usual dose: 1 mg/wk up to 4.5 mg. |
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| Oral |
| AS MONOTHERAPY IN PARKINSON'S DISEASE |
| Adult:
Initially, 0.5 mg daily in monotherapy and 1 mg daily as adjunct, may increase in increments of 0.5-1 mg at 7- or 14-day intervals. Max: 3 mg daily.
Elderly: Start with lower doses |
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| Oral |
| ADJUNCT TO LEVODOPA TREATMENT IN PARKINSON'S DISEASE |
| Adult:
Initially, 0.5 mg daily in monotherapy and 1 mg daily as adjunct, may increase in increments of 0.5-1 mg at 7- or 14-day intervals. Max: 3 mg daily.
Elderly: Start with lower doses. |
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| Administration |
Should be taken with food. |
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| Precautions |
CV disease, Raynaud's syndrome, renal or hepatic impairment, peptic ulcer, GI bleeding, history of serious mental disease, hypertension. May affect ability to drive or operate machinery. Pregnancy or the desire to start or continue breastfeeding. If at risk of pregnancy, mechanical contraception is recommended during treatment. Regular gynaecological assessment is recommended during prolonged treatment. |
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| Adverse Drug Reactions |
Decrease in BP, dizziness, vertigo, headache, nausea, sleeplessness, abdominal pain, dyspepsia, gastritis, weakness, fatigue, constipation, vomiting, breast pain, hot flushes, depression, tingling, leg cramps, Raynaud's syndrome, psychosis with hallucinations, delusions and confusion. Effects are dose-related and may be more frequent at higher doses. |
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| Interactions |
Antihypertensives, dopamine antagonists e.g. phenothiazines, butyrophenone, thioxanthines, metoclopramide; domperidone, octreotide, macrolides, psychotropics, antipsychotics. |
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