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Indication & Dosage |
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| Oral |
| TREATMENT OF EPILEPSY |
| Adult:
Initially, 100-200 mg once or bid gradually increased by increments of 100-200 mg every 2 wk. Maintenance: 0.8-1.2 g daily in divided doses. Max dose: 2 g daily. |
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| Oral |
| TREATMENT OF EPILEPSY |
| Child:
≤1 yr: 100-200 mg daily, 1-5 yr: 200-400 mg daily, 5-10 yr: 400-600 mg daily, 10-15 yr: 0.6-1 g daily. Alternatively, 10-20 mg/kg daily in divided doses. |
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| Oral |
| TRIGEMINAL NEURALGIA |
| Adult:
Initially, 100 mg once or bid gradually increased as necessary. Maintenance: 400-800 mg daily in 2-4 divided doses. Max: 1.2 g daily |
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| Rectal |
| TREATMENT OF EPILEPSY |
| Adult:
250 mg every 6 hr for patients incapable of oral treatment |
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| Oral |
| PROPHYLAXIS OF BIPOLAR DISORDER |
| Adult:
Initially, 400 mg daily in divided doses gradually increased if necessary. Maintenance: 400-600 mg daily. Max: 1.6 g daily. |
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| Administration |
Should be taken with food. (Avoid grapefruit juice.) |
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| Precautions |
Lactation; CV disease, hepatic or renal disorders, history of blood disorders or haematological reactions to other drugs; glaucoma; skin disorders; elderly, patients on MAO inhibitors; abrupt withdrawal of treatment. |
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Potentially Life-threatening
Adverse Drug Reactions |
Dizziness, drowsiness, ataxia; dry mouth, abdominal pain, nausea, vomiting, anorexia; leucopenia, proteinuria, renal failure, heart failure and hyponatraemia. |
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| Adverse Drug Reactions |
Agranulocytosis, aplastic anaemia, hepatic failure, severe exfoliative dermatitis and Stevens-Johnson syndrome. |
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| Interactions |
Reduces tolerance to alcohol; shortens T½ of doxycycline. Decreased efficacy of oral contraceptives when used with carbamazepine. Increased plasma concentrations of carbamazepine by propoxyphene. Serum level decreases with phenytoin, phenobarbital, primidone. |
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