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Indication & Dosage |
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Intramuscular |
TERMINATION OF PREGNANCY 2ND TRIMESTER |
Adult:
As tromethamine: 250 mcg deep IM, repeated at 1.5 to 3.5-hr intervals depending on uterine response. May be increased to 500 mcg if necessary. |
Max Dosage: 12 mg. |
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Intramuscular |
POSTPARTUM HAEMORRHAGE |
Adult:
As tromethamine: 250 mcg deep IM at 15- to 90-min intervals |
Max Dosage: 2 mg |
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Precautions |
Cardiopulmonary disorders, glaucoma, asthma, epilepsy, severe hepatic or renal dysfunction, labour. |
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Potentially Life-threatening
Adverse Drug Reactions |
Nausea, vomiting, diarrhoea, abdominal pain, flushing, shivering, headache, dizziness and hypotension, temporary pyrexia, dyspnoea, pulmonary oedema. |
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Adverse Drug Reactions |
Severe CVS disorders including fatal hypotension, tachypnea, pyrexia and MI (in patients with high risk factors) following intra-amniotic or intravaginal admin. Convulsions and ECG changes, amniotic fluid embolism and uterine rupture, foetal distress and rarely foetal death during induction of labour. |
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Interactions |
Enhances action of oxytocin hence both drugs should be used sequentially and carefully monitored. Action enhanced by prior inj of hyperosmolar urea. |
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