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testing

 
   
DEVIPROST  PROSTODIN 
 



Indication & Dosage
 
 
Intramuscular
TERMINATION OF PREGNANCY 2ND TRIMESTER
Adult: As tromethamine: 250 mcg deep IM, repeated at 1.5 to 3.5-hr intervals depending on uterine response. May be increased to 500 mcg if necessary.
Max Dosage:  12 mg.
 
Intramuscular
POSTPARTUM HAEMORRHAGE
Adult: As tromethamine: 250 mcg deep IM at 15- to 90-min intervals
Max Dosage:  2 mg
   
Precautions Cardiopulmonary disorders, glaucoma, asthma, epilepsy, severe hepatic or renal dysfunction, labour.
   
Potentially Life-threatening 
Adverse Drug Reactions
Nausea, vomiting, diarrhoea, abdominal pain, flushing, shivering, headache, dizziness and hypotension, temporary pyrexia, dyspnoea, pulmonary oedema.
   
Adverse Drug Reactions Severe CVS disorders including fatal hypotension, tachypnea, pyrexia and MI (in patients with high risk factors) following intra-amniotic or intravaginal admin. Convulsions and ECG changes, amniotic fluid embolism and uterine rupture, foetal distress and rarely foetal death during induction of labour.
   
Interactions

Enhances action of oxytocin hence both drugs should be used sequentially and carefully monitored.

Action enhanced by prior inj of hyperosmolar urea.

   
   
 

 

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