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Indication & Dosage |
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| Parenteral |
| SUSCEPTIBLE INFECTIONS |
| Adult:
As sodium: 0.5-1 g deep IM, slow IV Inj over 3-5 min or as iv infusion every 6-12 hr. Max: Up to 6-12 g daily for life-threatening infections. |
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| Parenteral |
| SUSCEPTIBLE INFECTIONS |
| Child:
>1 mth: 25-50 mg/kg daily in 3 or 4 divided doses. Max: Up to 100 mg/kg daily for severe infections. |
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| Parenteral |
| PROPHYLAXIS OF INFECTION DURING SURGERY INCLUDING PROPHYLAXIS OF ENDOMETRIOSIS DURING CAESARIAN SECTION |
| Adult:
As sodium: 1 g given 0.5-1 hr before surgery followed by 0.5-1 g during surgery for lengthy procedures; 0.5-1 g every 6-8 hrly may be given after surgery for 24 hr or up to 5 days.
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| Precautions |
Impaired renal function; pregnancy, lactation. Consider possibility of pseudomembranous colitis in patients who present with diarrhoea after antimicrobial usage. Risk of seizures in patients on high doses, especially in renally impaired patients. May decrease prothrombin activity; monitor prothrombin time in patients at risk e.g. those on anticoagulant treatment, prolonged antimicrobial treatment or those with renal or hepatic impairment. |
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Potentially Life-threatening
Adverse Drug Reactions |
Superinfection; nausea, vomiting, abdominal pain, anorexia, diarrhoea; rash, leukopenia, thrombocytopaenia, haemorrhage, elevated transaminases. |
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| Adverse Drug Reactions |
Anaphylactic reaction; pseudomembranous colitis. |
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| Interactions |
Probenecid reduces tubular secretion of cefazolin thereby prolonging its half-life. Disulfiram-like reaction with alcohol. |
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