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Indication & Dosage
 
 
Parenteral
MILD TO MODERATE UNCOMPLICATED OR COMPLICATED UTIS, INCLUDING PYELONEPHRITIS
Adult: 0.5-1 g IV/IM every 12 hr for 7-10 days.
 
Parenteral
EMPIRIC THERAPY FOR FEBRILE NEUTROPENIC PATIENTS
Adult: 2 g IV every 8 hr for 7 days.
 
Parenteral
MODERATE TO SEVERE PNEUMONIA
Adult: 1-2 g IV every 12 hr for 10 days
 
Parenteral
COMPLICATED INTRA-ABDOMINAL INFECTIONS
Adult: 2 g every 12 hr for 7-10 days. Usually used in combination with metronidazole.
 
Parenteral
MODERATE TO SEVERE UNCOMPLICATED SKIN AND SKIN STRUCTURE INFECTIONS
Adult: 2 g IV/IM every 12 hr for 10 days
   
Precautions Severe renal impairment; history of penicillin or cephalosporin allergy; lactation.
   
Adverse Drug Reactions Positive Coombs' test without haemolysis; rash, pruritus; diarrhoea, nausea, vomiting; fever, headache; pain and erythema at Inj site; agranulocytosis; anaphylactic shock; leucopenia; neutropenia; thrombocytopenia.
   
Interactions Increased effect with high-dose probenecid; increased nephrotoxic potential with aminoglycosides.
   
   
 

 

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