 |
Indication & Dosage |
| |
| |
| Parenteral |
| SUSCEPTIBLE INFECTIONS |
| Adult:
1-2 g every 8-12 hr given as deep IM or slow IV Inj over 3-5 min, increased to 2-4 g IV every 8 hr in severe infections. Max dose: 2 g every 4 hr. |
| |
| Intramuscular |
| UNCOMPLICATED GONORRHOEA |
| Adult:
1 g as a single dose. |
| |
| Parenteral |
| SUSCEPTIBLE INFECTIONS |
| Child:
>6 mth: 50 mg/kg every 6-8 hr. |
| |
| Parenteral |
| UNCOMPLICATED URINARY TRACT INFECTIONS |
| Adult:
0.5 g every 12 hr. |
|
| |
|
| Precautions |
Hypersensitivity to penicillins; severe renal impairment; pregnancy, lactation. |
| |
|
Potentially Life-threatening
Adverse Drug Reactions |
Burning; rash, pruritus, fever; anorexia, nausea, vomiting, diarrhoea; rarely neutropaenia, leucopaenia, thrombocytopaenia. Transient elevations of transaminases (SGOT and SGPT) and alkaline phosphatase, transient rise in BUN and creatinine. |
| |
|
| Adverse Drug Reactions |
Anaphylactoid reactions, nephrotoxicity, pseudomembranous colitis, |
| |
|
| Interactions |
Renal clearance reduced with probenecid. |
| |
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