| |
| |
| Parenteral |
| GONORRHOEA |
| Adult:
1-2 g daily as a single or in 2 divided doses given as deep IM inj or slow IV inj over 2-4 minutes or as infusion over at least 30 minutes, increased to 4 g daily in severe infections. |
| |
| Parenteral |
| MENINGITIS |
| Child:
<50 kg: 25-50 mg/kg once daily increased to 80 mg/kg in severe infections. Doses >50 mg/kg should be given as IV infusion. IV infusion in neonates should be given over 60 min. Max dose (neonates): 50 mg/kg/day. |
| |
| Parenteral |
| MENINGITIS |
| Adult:
1-2 g daily as a single or in 2 divided doses given as deep IM inj or slow IV inj over 2-4 minutes or as infusion over at least 30 minutes, increased to 4 g daily in severe infections. |
| |
| Parenteral |
| TYPHOID FEVER |
| Child:
<50 kg: 25-50 mg/kg once daily increased to 80 mg/kg in severe infections. Doses >50 mg/kg should be given as IV infusion. IV infusion in neonates should be given over 60 min. Max dose (neonates): 50 mg/kg/day. |
| |
| Parenteral |
| TYPHOID FEVER |
| Adult:
1-2 g daily as a single or in 2 divided doses given as deep IM inj or slow IV inj over 2-4 minutes or as infusion over at least 30 minutes, increased to 4 g daily in severe infections. |
| |
| Parenteral |
| WHIPPLE'S DISEASE |
| Child:
<50 kg: 25-50 mg/kg once daily increased to 80 mg/kg in severe infections. Doses >50 mg/kg should be given as IV infusion. IV infusion in neonates should be given over 60 min. Max dose (neonates): 50 mg/kg/day. |
| |
| Parenteral |
| WHIPPLE'S DISEASE |
| Adult:
1-2 g daily as a single or in 2 divided doses given as deep IM inj or slow IV inj over 2-4 minutes or as infusion over at least 30 minutes, increased to 4 g daily in severe infections. |
| |
| Intramuscular |
| UNCOMPLICATED GONORRHOEA |
| Adult:
250 mg as a single dose. |
| |
| Intramuscular |
| PREVENTION OF SECONDARY MENINGOCOCCAL MENINGITIS |
| Adult:
250 mg as a single dose. |
| |
| Intramuscular |
| PREVENTION OF SECONDARY MENINGOCOCCAL MENINGITIS |
| Child:
125 mg as a single dose. |
| |
| Parenteral |
| GONORRHOEA |
| Child:
<50 kg: 25-50 mg/kg once daily increased to 80 mg/kg in severe infections. Doses >50 mg/kg should be given as IV infusion. IV infusion in neonates should be given over 60 min. Max dose (neonates): 50 mg/kg/day. |
| |
| Parenteral |
| ENDOCARDITIS |
| Adult:
1-2 g daily as a single or in 2 divided doses given as deep IM inj or slow IV inj over 2-4 minutes or as infusion over at least 30 minutes, increased to 4 g daily in severe infections. |
| |
| Parenteral |
| ENDOCARDITIS |
| Child:
<50 kg: 25-50 mg/kg once daily increased to 80 mg/kg in severe infections. Doses >50 mg/kg should be given as IV infusion. IV infusion in neonates should be given over 60 min. Max dose (neonates): 50 mg/kg/day. |
| |
| Parenteral |
| CHANROID |
| Adult:
1-2 g daily as a single or in 2 divided doses given as deep IM inj or slow IV inj over 2-4 minutes or as infusion over at least 30 minutes, increased to 4 g daily in severe infections. |
| |
| Parenteral |
| CHANROID |
| Child:
<50 kg: 25-50 mg/kg once daily increased to 80 mg/kg in severe infections. Doses >50 mg/kg should be given as IV infusion. IV infusion in neonates should be given over 60 min. Max dose (neonates): 50 mg/kg/day. |
| |
| Parenteral |
| GASTROENTERITIS |
| Adult:
1-2 g daily as a single or in 2 divided doses given as deep IM inj or slow IV inj over 2-4 minutes or as infusion over at least 30 minutes, increased to 4 g daily in severe infections. |
| |
| Parenteral |
| GASTROENTERITIS |
| Child:
<50 kg: 25-50 mg/kg once daily increased to 80 mg/kg in severe infections. Doses >50 mg/kg should be given as IV infusion. IV infusion in neonates should be given over 60 min. Max dose (neonates): 50 mg/kg/day. |
| |
| Parenteral |
| LYME DISEASE |
| Adult:
1-2 g daily as a single or in 2 divided doses given as deep IM inj or slow IV inj over 2-4 minutes or as infusion over at least 30 minutes, increased to 4 g daily in severe infections. |
| |
| Parenteral |
| LYME DISEASE |
| Child:
<50 kg: 25-50 mg/kg once daily increased to 80 mg/kg in severe infections. Doses >50 mg/kg should be given as IV infusion. IV infusion in neonates should be given over 60 min. Max dose (neonates): 50 mg/kg/day. |
| |
| Parenteral |
| SEPTICAEMIA |
| Adult:
1-2 g daily as a single or in 2 divided doses given as deep IM inj or slow IV inj over 2-4 minutes or as infusion over at least 30 minutes, increased to 4 g daily in severe infections. |
| |
| Parenteral |
| SEPTICAEMIA |
| Child:
<50 kg: 25-50 mg/kg once daily increased to 80 mg/kg in severe infections. Doses >50 mg/kg should be given as IV infusion. IV infusion in neonates should be given over 60 min. Max dose (neonates): 50 mg/kg/day. |
| |
| Parenteral |
| SYPHILIS |
| Adult:
1-2 g daily as a single or in 2 divided doses given as deep IM inj or slow IV inj over 2-4 minutes or as infusion over at least 30 minutes, increased to 4 g daily in severe infections. |
| |
| Parenteral |
| SYPHILIS |
| Child:
<50 kg: 25-50 mg/kg once daily increased to 80 mg/kg in severe infections. Doses >50 mg/kg should be given as IV infusion. IV infusion in neonates should be given over 60 min. Max dose (neonates): 50 mg/kg/day. |
| |
| Parenteral |
| PROPHYLAXIS FOR SURGICAL INFECTION |
| Adult:
1 g as a single dose given 0.5-2 hr prior to surgery via deep IM inj or slow IV inj over at least 2-4 minutes or IV infusion over at least 30 minutes. A 2 g dose is recommended for colorectal surgery. |
