Indication & Dosage |
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| Oral |
| NON-HODGKIN'S LYMPHOMA |
| Adult:
100 mcg/kg daily. Max: 100 mcg/kg/day if the bone marrow is hypoplastic or if there is lymphocytic infiltration in the bone marrow. Once remission is establised, start maintenance at 30-100 mcg/kg/day |
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| Oral |
| HODGKIN'S DISEASE |
| Adult:
200 mcg/kg daily. Max: 100mcg/kg/day if the bone marrow is hypoplastic or if there is lymphocytic infiltration in the bone marrow. Once remission is establised, start maintenance at 30-100 mcg/kg/day. |
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| Oral |
| CHRONIC LYMPHOCYTIC LEUKAEMIA |
| Adult:
100-200 mcg/kg daily (usually 4-10 mg once daily) for 3-8 wk. Max: 100 mcg/kg/day if the bone marrow is hypoplastic or if there is lymphocytic infiltration in the bone marrow. Once remission is establised, start maintenance at 30-100 mcg/kg/day. |
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| Oral |
| WALDENSTROM'S MACROGLOBULINAEMIA |
| Adult:
Initially, 6-12 mg daily until leucopenia develops. Maintenance: 2-8 mg daily. |
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| Administration |
Should be taken on an empty stomach (i.e. At least one hour before food or four hours after food). (Take on an empty stomach. Ensure adequate hydration. Swallow whole, do not chew/crush.) |
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| Precautions |
Renal or hepatic dysfunction. Perform blood counts regularly. Seizure disorder, bone marrow suppression. Patient who has received radiation therapy, myelosuppressive drugs or has a depressed baseline leukocyte/platelet count within the previous 4 wk. Increased incidence of acute leukaemias and other secondary malignancies. |
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Potentially Life-threatening
Adverse Drug Reactions |
Reversible progressive lymphocytopenia and neutropenia; GI disturbances; hepatotoxicity; skin rashes; peripheral neuropathy; central neurotoxicity including seizures; interstitial pneumonia, pulmonary fibrosis. High doses may produce azoospermia and amenorrhoea. Sterility when given to boys at or before puberty. |
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| Adverse Drug Reactions |
Severe bone marrow suppression, carcinogenic and human infertility. |
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| Interactions |
Impairs immune response to vaccines, possible infection after admin of live vaccines. |
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