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Indication & Dosage
 
 
Oral
CONTROL OF ACUTE SYMPTOMS OF ALCOHOL WITHDRAWAL
Adult:

25-100 mg daily repeated as necessary. Max dose: 300 mg daily.

Elderly: and debilitated patients: Dose reduction may be needed.

 
Oral
RELIEF OF MUSCLE SPASM
Adult:

10-30 mg daily in divided doses.

Elderly: and debilitated patients: Dose reduction may be needed.

 
Oral
TREATMENT OF ANXIETY
Adult: 30 mg daily in divided doses, up to 100 mg daily in severe conditions.
 
Oral
INSOMNIA
Adult:

10-30 mg before bedtime.

Elderly: and debilitated patients: Dose reduction may be needed.

 
Intramuscular
PREMEDICATION IN ANAESTHESIA
Adult:

50-100 mg given 1 hr before surgery.

Elderly: and debilitated patients: Dose reduction may be needed.

 
Parenteral
TREATMENT OF ACUTE OR SEVERE ANXIETY
Adult:

Initially, 50-100 mg followed by 25-50 mg 3-4 times daily if necessary. May be given via deep IM or slow IV inj.

Elderly: and debilitated patients: Dose reduction may be needed.

 
Parenteral
CONTROL OF SEVERE SYMPTOMS OF ALCOHOL WITHDRAWAL
Adult:

Initially, 50-100 mg, if necessary, repeat dose after 2-4 hr. May be given via deep IM or slow IV inj.

Elderly: and debilitated patients: Dose reduction may be needed.

   
Administration May be taken with or without food.
   
Precautions Alcohol; sedation, dependence. Elderly and debilitated patients. Liver or kidney dysfunction. Avoid prolonged usage.
   
Potentially Life-threatening 
Adverse Drug Reactions
Physical and psychological dependence; withdrawal syndrome; impairs psychomotor performance, aggression (in predisposed individuals esp in combination with alcohol); sedation; blood dyscrasias, jaundice, hepatic dysfunction.
   
Adverse Drug Reactions May rarely cause hypoplastic or haemolytic anaemia.
   
Interactions Cimetidine increases serum conc of chlordiazepoxide. Potentiates action of major neuroleptics.
   
   
 

 

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