Indication & Dosage |
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| Oral |
| TREATMENT OF DYSPEPSIA |
| Adult:
10 mg tid and at bedtime for 4 wk. |
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| Oral |
| TREATMENT OF DISORDERS ASSOCIATED WITH DECREASED GI MOTILITY |
| Adult:
5-10 mg 3-4 times daily. Max: 40 mg/day |
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| Oral |
| TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE WITH OR WITHOUT OESOPHAGITIS INCLUDING EROSIONS AND ULCERATIONS |
| Adult:
5-10 mg 3-4 times daily. Max: 40 mg/day |
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| Administration |
Should be taken on an empty stomach (i.e. At least one hour before food or four hours after food). (Take 15 mins before meals. Avoid grapefruit juice.) |
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| Precautions |
Elderly; renal or hepatic impairment. Patients in whom increase in GI motility could be harmful. Lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Sedative effects of benzodiazepines and alcohol may be enhanced. Prothrombin time in patients on anticoagulants may be increased. Effect antagonised by anticholinergic drugs. Avoid cisapride with antiallergics, antibacterials, antidepressants, antifungals, antinauseants, antipsychotics and protease-inhibitors. Cisapride increases the GI absorption of cimetidine and ranitidine. Grapefruit juice increases bioavailability of cisapride, avoid concomitant use. |
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| Adverse Drug Reactions |
Abdominal cramps, borborygmi and loose stools (transient); rarely require discontinuation of therapy. Headache and lightheadedness (rare). Hypersensitivity, convulsions, frequent urination. |
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| Interactions |
Food increases the bioavailability. |
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