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Indication & Dosage |
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| Oral |
| TREATMENT OF DEPRESSION |
| Adult:
Initially, 20 mg daily, increased to 40 mg once daily after at least 1 wk or 60 mg daily if necessary. |
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| Oral |
| TREATMENT OF PANIC DISORDER WITH OR WITHOUT AGORAPHOBIA |
| Adult:
Initially, 20 mg daily, increased to 40 mg once daily after at least 1 wk or 60 mg daily if necessary. |
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| Intravenous |
| TREATMENT OF DEPRESSION |
| Adult:
Initially, 10 mg daily, increased to 20 mg daily after 1 wk. Max: 60 mg daily. |
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| Administration |
May be taken with or without food. |
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| Precautions |
Gradual discontinuation of treatment if patient enters into manic phase; pregnancy. Increased risk of hyponatraemia and SIADH. May reduce convulsant threshold thus, citalopram should be used with care in epileptic patients. |
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Potentially Life-threatening
Adverse Drug Reactions |
Increased sweating, headache, tremor, fatigue, asthenia, dizziness, abnormal accommodation, somnolence, insomnia, agitation, nervousness, nausea, dry mouth, constipation, diarrhoea, palpitation, rash, pruritus, abnormal vision, decreased libido, anxiety, increased appetite, anorexia, apathy, impotence, suicide attempt, confusion, yawning, dyspepsia, vomiting, abdominal pain, flatulence, increased saliva, weight decrease or increase, postural hypotension, tachycardia, rhinitis, ejaculation failure, fatigue, extrapyramidal disorders. |
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| Adverse Drug Reactions |
Increased risk of suicidal thinking and behaviour especially in child and adolescents. Monitor closely for signs of clinical worsening, suicidality or unusual changes in behaviour. |
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| Interactions |
Do not start MAOI therapy until at least 2 wk after SSRIs withdrawal; serotonergic effects are suspected to be enhanced by SSRIs. May increase anticoagulant effect when used with warfarin. |
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