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Indication & Dosage |
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| Oral |
| MULTIBACILLARY LEPROSY |
| Adult:
300 mg clofazimine with 600 mg rifampicin, both given once a mth together with 50 mg clofazimine and 100 mg dapsone daily for 12 mth. |
| |
| Oral |
| MULTIBACILLARY LEPROSY |
| Child:
10-14 yr: 150 mg clofazimine with 450 mg rifampicin and 50 mg dapsone once a mth, taken with 50 mg dapsone daily and 50 mg clofazimine on alternate days. Treatment is given for 12 mth. |
| |
| Oral |
| TYPE 2 LEPRA REACTIONS |
| Adult:
300 mg clofazimine with 600 mg rifampicin, both given once a mth together with 50 mg clofazimine and 100 mg dapsone daily for 12 mth. |
| |
| Oral |
| MYCOBACTERIUM AVIUM COMPLEX INFECTIONS |
| Adult:
300 mg clofazimine with 600 mg rifampicin, both given once a mth together with 50 mg clofazimine and 100 mg dapsone daily for 12 mth. |
| |
| Oral |
| MYCOBACTERIUM AVIUM COMPLEX INFECTIONS |
| Child:
300 mg clofazimine with 600 mg rifampicin, both given once a mth together with 50 mg clofazimine and 100 mg dapsone daily for 12 mth. |
| |
| Oral |
| LEPROSY |
| Adult:
300 mg clofazimine with 600 mg rifampicin, both given once a mth together with 50 mg clofazimine and 100 mg dapsone daily for 12 mth. |
| |
| Oral |
| ERYTHEMA NODOSUM LEPROSUM (TYPE 2) |
| Adult:
300 mg clofazimine with 600 mg rifampicin, both given once a mth together with 50 mg clofazimine and 100 mg dapsone daily for 12 mth. |
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| Administration |
Should be taken with food. |
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| Precautions |
Pregnancy. Patients with GI symptoms. |
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Potentially Life-threatening
Adverse Drug Reactions |
Red-brownish black discolouration of skin especially areas exposed to sunlight, hair, sweat, sputum, urine, faeces. Rash, pruritus, photosensitivity, diarrhoea, nausea, abdominal pain, vomiting, weight loss, headache, drowsiness, dizziness, taste disorders, dryness of the skin, ichthyosis, decreased tear and sweat production. |
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| Adverse Drug Reactions |
Crystal depletion in the wall of small bowel mesenteric lymph nodes, liver and spleen. Severe abdominal symptoms including bowel obstruction, GI bleeding and splenic infarction. |
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