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Indication & Dosage |
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| Oral |
| TREATMENT OF ALL TYPES OF EPILEPSY |
| Adult:
Initially, 1 mg given at night for 4 nights, gradually increased over 2-4 wk. Maintenance: 4-8 mg daily. Max: 20 mg/day |
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| Oral |
| TREATMENT OF ALL TYPES OF EPILEPSY |
| Child:
1-5 yr: 250 mcg daily; 5-12 yr: 500 mcg daily. Maintenance (given in 2-4 divided doses): Infants: 0.5-1 mg daily; 1-5 yr: 1-3 mg daily; 5-12 yr: 3-6 mg daily. Max: 200 mcg/kg/day
Elderly: Initially, 500 mcg at night for 4 nights, may gradually increase over 2-4 wk |
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| Oral |
| TREATMENT OF PANIC DISORDER |
| Adult:
Initially, 250 mcg bid, increased after 3 days up to 1 mg daily. Max: 4 mg daily. |
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| Intravenous |
| EMERGENCY MANAGEMENT OF STATUS EPILEPTICUS |
| Adult:
1 mg as inj or infusion given over at least 2 min, repeated if necessary. |
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| Oral |
| EMERGENCY MANAGEMENT OF STATUS EPILEPTICUS |
| Child:
and infants: 500 mcg as inj or infusion given over at least 2 min, repeated if necessary. |
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| Administration |
May be taken with or without food. |
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| Precautions |
Neonates, chronic pulmonary insufficiency, hepatic/renal dysfunction, porphyria, elderly; pregnancy and lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Drowsiness, fatigue, muscular hypotonia, coordination disturbances, dizziness, vertigo, anorexia, visual disturbances, libido changes. |
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| Adverse Drug Reactions |
Salivary or bronchial hypersecretion leading to respiratory problems (children). May produce diminished reflexes or coma. Rarely, blood dyscrasias. |
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| Interactions |
Carbamazepine, phenobarbitone or phenytoin may accelerate clonazepam metabolism. |
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