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Indication & Dosage |
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| Oral |
| ENDOMETRIOSIS |
| Adult:
200-800 mg daily in 2 divided doses adjusted according to response, for 3-6 mth or if necessary, up to 9 mth. |
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| Oral |
| BENIGN BREAST DISORDERS |
| Adult:
Initially, 100-400 mg daily in 2 divided doses adjusted according to response and continued for 3-6 mth. |
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| Oral |
| GYNAECOMASTIA |
| Adult:
Male adolescents: Initially, 200 mg daily, may increase to 400 mg daily after 2 mth if no response occurs; adult men: Initial: 400 mg daily in up to 4 divided doses. Usual treatment duration: 6 mth. |
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| Oral |
| GYNAECOMASTIA |
| Child:
Male adolescents: Initially, 200 mg daily increased to 400 mg after 2 mth if no response occurs. Treatment usually up to 6 months. |
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| Oral |
| HEREDITARY ANGIOEDEMA |
| Adult:
Initially, 200 mg bid-tid reduced thereafter according to patient's response. |
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| Oral |
| PREOPERATIVE THINNING OF THE ENDOMETRIUM |
| Adult:
400-800 mg daily, in up to 4 divided doses for 3-6 wk. |
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| Oral |
| MENORRHAGIA |
| Adult:
200 mg once daily. Review treatment 3 mth later |
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| Administration |
May be taken with or without food. (Take consistently either always w/ or always without meals.) |
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| Precautions |
Epilepsy, migraine; cardiac, hepatic, renal disorders. Severe hypertension, diabetes, polycythaemia, history of thrombosis; children. |
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Potentially Life-threatening
Adverse Drug Reactions |
Oedema, wt gain, sweating, acne, hirsutism, flushing, oily skin or hair, deepening of the voice, clitoral hypertrophy, amenorrhoea, hepatic dysfunction, CNS or GI disturbances, benign intracranial hypertension, reduction in breast size, visual disturbances, elevated LFT values. |
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| Adverse Drug Reactions |
Thromboembolic events and fatal strokes have been reported. |
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| Interactions |
Increased incidence of insulin resistance in diabetic patients. Increased serum levels of ciclosporin, warfarin, carbamazepine and tacrolimus. |
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