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Indication & Dosage |
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| Oral |
| MULTIBACILLARY LEPROSY |
| Adult:
100 mg daily with clofazimine 50 mg daily, together with rifampicin 600 mg and clofazimine 300 mg once a mth for 12 mth. <35 kg: dapsone dose: 1-2 mg/kg/day. |
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| Oral |
| PRIMARY AND SECONDARY PROPHYLAXIS OF PNEUMOCYSTIS PNEUMONIA |
| Child:
1 mth-18 yr: 2 mg/kg daily (max: 100 mg daily) or 4 mg/kg wkly (max: 200 mg wkly). |
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| Oral |
| PRIMARY AND SECONDARY PROPHYLAXIS OF PNEUMOCYSTIS PNEUMONIA |
| Adult:
50 mg daily, with pyrimethamine 50 mg once wkly. Alternatively, 100 mg with pyrimethamine 50 mg twice wkly. |
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| Oral |
| MULTIBACILLARY LEPROSY |
| Child:
and child 10-14 yr old: daily doses of dapsone 50 mg, or 1 to 2 mg/kg if their body-weight is low |
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| Oral |
| PAUCIBACILLARY LEPROSY |
| Adult:
100 mg daily with 600 mg rifampicin once a mth, both given for 6 mth. |
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| Oral |
| PAUCIBACILLARY LEPROSY |
| Child:
Reduce dose as for multibacillary leprosy. |
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| Oral |
| DERMATITIS HERPETIFORMIS |
| Adult:
Initially, 50 mg daily increased gradually to 300 mg daily if required. |
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| Administration |
Should be taken with food. |
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| Precautions |
G6PD deficiency, methaemoglobin or Hb M. Perform regular blood counts and monitor liver function regularly. Pregnancy and lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Anaemia, peripheral neuropathy, haemolysis and methaemoglobinaemia (dose-related), nephrotic syndrome, psychological changes, hepatitis. Others: Nausea, vomiting, anorexia, headache, maculopapular rash, toxic epidermal necrolysis, Stevens-Johnson syndrome. |
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| Adverse Drug Reactions |
Agranulocytosis, serious cutaneous hypersensitivity reactions, exfoliative dermatitis. |
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| Interactions |
Decreased serum conc of dapsone when used with rifampicin. Increased plasma conc with probenecid, trimethoprim. Antagonize clofazimine. |
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