Indication & Dosage |
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| Oral |
| SUSCEPTIBLE INFECTIONS CAUSED BY BOTH GRAM-NEGATIVE AND GRAM-POSITIVE BACTERIA |
| Adult:
>8 yr: 7-13 mg/kg daily divided every 6-12 hr. |
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| Oral |
| SUSCEPTIBLE INFECTIONS CAUSED BY BOTH GRAM-NEGATIVE AND GRAM-POSITIVE BACTERIA |
| Adult:
150 mg four times daily or 300 mg bid. |
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| Oral |
| ATYPICAL PNEUMONIA |
| Adult:
300 mg tid. |
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| Oral |
| CHRONIC HYPONATRAEMIA ASSOCIATED WITH SIADH |
| Adult:
Initial dose: 900-1200 mg/day in divided doses. Maintenance dose: 600-900 mg/day in divided doses. |
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| Administration |
Should be taken on an empty stomach (i.e. At least one hour before food or four hours after food). (Take w/ a full glass of water on an empty stomach at least 1 hr before or 2 hr after meals.) |
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| Precautions |
Children <12 yr; SLE; renal or hepatic disease. |
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Potentially Life-threatening
Adverse Drug Reactions |
Photosensitivity. Reversible nephrogenic diabetes insipidus. Permanent staining of teeth; nausea; rash; GI upsets; dysphagia; enterocolitis; anogenital inflammation (moniliasis). Hypersensitivity; haemolytic anaemia, thrombocytopenia, neutropenia and eosinophilia; raised blood urea and liver enzymes. |
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| Adverse Drug Reactions |
Anaphylaxis (rare). |
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| Interactions |
Antacids, milk, calcium, magnesium and iron preparations reduce absorption. Diuresis induced by amiloride and metolazone may be enhanced. May reduce efficacy of oral contraceptives when used concurrently. |
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