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Indication & Dosage
 
 
Nasal
RENAL FUNCTION TESTING
Child: 1-15 yr: 20 mcg and infants: 10 mcg. To be given as a single dose.
 
Nasal
RENAL FUNCTION TESTING
Adult: 40 mcg as a single dose.
 
Nasal
DIAGNOSIS OF DIABETES INSIPIDUS
Child: 20 mcg as a single dose.
 
Nasal
DIAGNOSIS OF DIABETES INSIPIDUS
Adult: 20 mcg as a single dose.
 
Nasal
CRANIAL DIABETES INSIPIDUS
Child: 3 mth-12 yr: 5-30 mcg daily.
 
Nasal
CRANIAL DIABETES INSIPIDUS
Adult: 10-40 mcg daily as a single or divided doses
 
Parenteral
RENAL FUNCTION TESTING
Child: Infants: 0.4 mcg; children: 2 mcg. Dose to be given as SC or IM inj.
 
Oral
CRANIAL DIABETES INSIPIDUS
Adult: Initially, 100 mcg tid adjusted according to response. Maintenance: 100-200 mcg tid, up to 100-1200 mcg daily.
 
Oral
PRIMARY NOCTURNAL ENURESIS
Adult: 200-400 mcg at bedtime.
 
Oral
CRANIAL DIABETES INSIPIDUS
Child: Initially, 100 mcg tid adjusted according to response. Maintenance: 100-200 mcg tid, up to 100-1200 mcg daily.
 
Oral
PRIMARY NOCTURNAL ENURESIS
Child: ≥5 yr: 200-400 mcg at bedtime.
 
Intravenous
TYPE I VON WILLEBRAND'S DISEASE
Adult: 0.3-0.4 mcg/kg by slow infusion over 15-30 min before surgery.
 
Intravenous
TESTING OF FIBRINOLYTIC RESPONSE
Adult: 0.4 mcg/kg infused over 20 min.
 
Intravenous
TESTING OF FIBRINOLYTIC RESPONSE
Child:  0.4 mcg/kg infused over 20 min.
 
Parenteral
CRANIAL DIABETES INSIPIDUS
Adult: 1-4 mcg daily IM, SC or IV.
 
Parenteral
CRANIAL DIABETES INSIPIDUS
Child: 0.4 mcg IM, SC, or IV.
 
Parenteral
DIAGNOSIS OF DIABETES INSIPIDUS
Adult: 2 mcg as a single dose via SC/IM.
 
Parenteral
DIAGNOSIS OF DIABETES INSIPIDUS
Child: 2 mcg SC/IM.
 
Parenteral
RENAL FUNCTION TESTING
Adult: 2 mcg given as SC or IM inj.
 
Nasal
PRIMARY NOCTURNAL ENURESIS
Adult: 20-40 mcg at bedtime.
 
Nasal
PRIMARY NOCTURNAL ENURESIS
Child: ≥5 yr: 20-40 mcg at bedtime
 
Nasal
NOCTURIA ASSOCIATED WITH MULTIPLE SCLEROSIS
Adult: 10-20 mcg at bedtime.
 
Nasal
TYPE I VON WILLEBRAND'S DISEASE
Adult: 300 mcg; <50 kg: 150 mcg. Should be given within 2 hr before the surgery.
   
Administration May be taken with or without food.
   
Precautions Not to be used in the treatment of Type IIb von Willebrand's disease and nephrogenic diabetes insipidus. Fluid intake restricted to a min and only to satisfy thirst for 8 hr after admin (particularly in the very young and the elderly). Nasal route avoided in patients with nasal mucosal diseases. Caution in CV diseases, oedema states, impairment, hypertension, elderly, cystic fibrosis, fluid and electrolyte imbalance, thrombotic disease; infants and young children. Inj not recommended for infants <3 mth for bleeding disorders. Pregnancy and lactation.
   
Potentially Life-threatening 
Adverse Drug Reactions
Nausea, transient headache; nasal congestion, rhinitis; flushing; mild abdominal cramps; epistaxis; sore throat, cough, stuffiness; allergic reactions, inj site pain, erythema, swelling, BP changes and thrombotic events in predisposed individuals.
   
Adverse Drug Reactions Water intoxication and dilutional hyponatraemia.
   
Interactions Drugs that may potentiate antidiuretic effect of desmopressin: chlorpropamide, clofibrate, carbamazepine, fludrocortisone, urea, or TCAs. Drugs that may decrease antidiuretic effect of desmopressin: lithium, heparin, demeclocycline, noradrenaline, and alcohol. Caution when using with other vasopressors.
   
   
 

 

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