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Indication & Dosage |
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| Oral |
| OSTEOARTHRITIS |
Adult:
Initial 50mg/day taken with evening meals for 4 wk, increasing to 50 mg bid with main meals, if tolerated.
In patients with CrCl <30 mL/min, doses should be halved. |
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| Administration |
Should be taken with food. (Take w/ or immediately after meals.) |
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| Precautions |
Renal impairment. Monitor CBC, LFT and urinalysis every 6 mth. |
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| Adverse Drug Reactions |
Diarrhoea, epigastric pain, nausea, vomiting, intense yellow colouring of urine. |
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| Interactions |
Decreased absorption with aluminium and/or magnesium hydroxide antacids. Increased risk of diarrhoea with laxatives, antibiotics. Avoid co-admin with fibres and phytates. |
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