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Indication & Dosage
 
 
Oral
SHORT-TERM TREATMENT OF ANXIETY DISORDERS
Adult: Adult: 2 mg tid. Max: 30 mg daily.
Elderly: Dose reduction may be required.
 
Oral
TREATMENT OF INSOMNIA ASSOCIATED WITH ANXIETY
Adult: 5-15 mg at bedtime. Elderly: Dose reduction may be required.
 
Oral
CONTROL OF SLEEPWALKING
Child: and adolescents (up to 18 yr): 1-5 mg at bedtime. Elderly: Dose reduction may be required.
 
Oral
NIGHT TERRORS
Adult: and adolescents (up to 18 yr): 1-5 mg at bedtime. Elderly: Dose reduction may be required.
 
Oral
PREMEDICATION FOR SURGERY
Adult: 5-15 mg given before general anaesthesia.
 
Oral
PREMEDICATION FOR SURGERY
Child: 1-12 mth: 250 mcg/kg; 1-5 yr: 2.5 mg; 5-12 yr: 5 mg. Elderly: Dose reduction may be required.
 
Oral
ADJUNCT IN THE MANAGEMENT OF SEIZURES
Adult: 2-60 mg daily in divided doses. Elderly: Dose reduction may be required.
 
Oral
RELIEF OF MUSCLE SPASMS
Adult: 2-15 mg daily in divided doses, increased up to 60 mg daily in severe spastic disorders e.g. cerebral palsy. Max: 60 mg/day.
Max Dosage:  60 mg/day.
 
Oral
RELIEF OF MUSCLE SPASMS
Child: 1-12 mth: 250 mcg/kg; 1-5 yr: 2.5 mg; 5-12 year: 5 mg; 12-18 yr: 10 mg. Max: 40 mg/day. Elderly: Dose reduction may be required.
 
Oral
CONTROL OF ACUTE SYMPTOMS OF ALCOHOL WITHDRAWAL
Adult: 5-20 mg repeated after 2-4 hr if necessary. Alternatively, 10 mg 3-4 times daily on the 1st day reduced to 5 mg 3-4 times daily as required. Elderly: Dose reduction may be required.
 
Intravenous
PREMEDICATION FOR SURGERY
Adult: 100-200 mcg/kg.
 
Intravenous
PREMEDICATION FOR SURGERY
Child: >1 mth: 100-200 mcg/kg. Max: 1 mth-12 yr: 5 mg/day; 12-18 yr: 20 mg/day. Elderly: Dose reduction may be required.
 
Parenteral
SHORT-TERM TREATMENT OF ANXIETY DISORDERS
Adult: 10 mg IM/IV repeated if necessary after 4 hr. Elderly: Dose reduction may be required.
 
Parenteral
RELIEF OF MUSCLE SPASMS
Adult: 10 mg IM/IV repeated if necessary after 4 hr. Elderly: Dose reduction may be required.
 
Intravenous
RELIEF OF MUSCLE SPASM ASSOCIATED WITH TETANUS
Adult: 100-300 mcg/kg given every 1-4 hr by IV inj. Alternatively, 3-10 mg/kg is given over 24 hr by continuous IV infusion or by nasoduodenal tube using a suitable liquid oral dose preparation.
 
Intravenous
RELIEF OF MUSCLE SPASM ASSOCIATED WITH TETANUS
Child: >1 mth: 100-300 mcg/kg given every 1-4 hr by IV inj. Alternatively, 3-10 mg/kg is given over 24 hr by continuous IV infusion or by nasoduodenal tube using a suitable liquid oral dose preparation. Elderly: Dose reduction may be required.
 
Parenteral
CONTROL OF ACUTE SYMPTOMS OF ALCOHOL WITHDRAWAL
Adult: 10-20 mg IM/IV if symptoms are severe and if delirium tremens has developed. Elderly: Dose reduction may be required
 
Rectal
SHORT-TERM TREATMENT OF ANXIETY DISORDERS
Adult: As rectal solution: 500 mcg/kg, repeated after 12 hr if necessary. As suppository: 10-30 mg. Elderly: Dose reduction may be required.
 
Rectal
PREMEDICATION FOR SURGERY
Adult: As a rectal solution: 500 mcg/kg. Elderly: Dose reduction may be required.
 
Rectal
ADJUNCT IN THE MANAGEMENT OF SEIZURES
Adult: As rectal gel: 200-500 mcg/kg, repeated after 4-12 hr if necessary
 
Rectal
ADJUNCT IN THE MANAGEMENT OF SEIZURES
Child: >2 yr: As rectal gel: 200-500 mcg/kg, repeated after 4-12 hr if necessary. Elderly: Dose reduction may be required
 
Rectal
RELIEF OF MUSCLE SPASM ASSOCIATED WITH TETANUS
Adult: As rectal solution: 500 mcg/kg repeated every 12 hr if necessary
 
Rectal
RELIEF OF MUSCLE SPASM ASSOCIATED WITH TETANUS
Child: >10 kg: As rectal solution: 500 mcg/kg repeated every 12 hr if necessary. Elderly: Dose reduction may be required.
   
Administration May be taken with or without food.
   
Precautions Impaired renal and hepatic function; chronic pulmonary insufficiency; organic cerebral changes; elderly; psychotic patients; epileptics; history of alcohol or drug addiction.
   
Potentially Life-threatening 
Adverse Drug Reactions
Psychological and physical dependence with withdrawal syndrome; fatigue, drowsiness, sedation, ataxia, vertigo, confusion, depression, GI disturbances, changes in salivation, amnesia, jaundice, paradoxical excitation, elevated liver enzyme values; muscle weakness, visual disturbances, headache, slurring of speech and dysarthria; mental changes; incontinence, constipation; hypotension, tachycardia; changes in libido; pain and thrombophloebitis at Inj site (IV).
   
Adverse Drug Reactions Respiratory and CNS depression; coma.
   
Interactions

Phenothiazines, barbiturates, MAOIs potentiate action of diazepam. Additive depressant effects with alcohol and CNS depressants. Mutual potentiation of action with analgesics, anaesthetics and some anticonvulsants.

Increased clearance of diazepam when used with phenytoin, carbamazepine and phenobarbital. Reversible deterioration of parkinsonism may occur when given together with levodopa. Combination with lithium may produce hypothermia.

 

   
   
 

 

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