Health Needs::Search Drugs

Should be taken on an empty stomach (i.e. At least one hour before food or four hours after food). (Take on an empty stomach ½ hr before or 2 hr after meals.)

Precautions

History of pancreatitis and liver disease; pregnancy; impaired hepatic and renal function; peripheral neuropathy; hyperuricaemia. Half-yrly dilated retinal examinations are recommended.

Potentially Life-threatening
Adverse Drug Reactions

Pancreatitis; peripheral neuropathy; diarrhoea, nausea, vomiting, abdominal pain; headache, fatigue, rash, hyperuricaemia; hepatic failure; retinal depigmentation, neuritis.

Adverse Drug Reactions

History of pancreatitis and liver disease; pregnancy; impaired hepatic and renal function; peripheral neuropathy; hyperuricaemia. Half-yrly dilated retinal examinations are recommended.

Interactions

Increased effect with allopurinol and ganciclovir; hydroxyurea; increased toxicity with ribavirin or tenofovir. Decreased effects of quinolones, tetracyclines, indinavir. Increased risk of pancreatitis when used with pentamidine, stavudine or co-trimoxazole.

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