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Indication & Dosage |
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| Oral |
| FILARIASIS; LOIASIS; TOXOCARIASIS |
| Adult:
Initially, 1 mg/kg daily, increased gradually to 6 mg/kg daily over 3 days then maintained for 3 wk. A corticosteroid may be given concurrently for the treatment of filarial infections. |
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| Oral |
| PROPHYLAXIS OF LOIASIS |
| Adult:
300 mg wkly. |
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| Precautions |
Patients with poor health. |
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Potentially Life-threatening
Adverse Drug Reactions |
Fever, headache, vomiting, dizziness, drowsiness, nausea, chills. |
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| Adverse Drug Reactions |
Severe hypersensitivity reactions may occur especially in the treatment of onchocerciasis where rare Mazzotti reaction characterised by rash, itching, headache, muscle and joint pains, tachycardia, postural hypotension may start within 2 hr of drug administration. Encephalitis and retinal haemorrhage. |
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