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Indication & Dosage |
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| Oral |
| PREVENTION AND TREATMENT OF MOTION SICKNESS |
| Adult:
50-100 mg given at least 30 min before traveling. |
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| Oral |
| PREVENTION AND TREATMENT OF MOTION SICKNESS |
| Child:
6-12 yr: 25-50 mg; 2-6 yr: 12.5-25 mg. Doses can be repeated every 6-8 hr. Max: 2-6 yr: 75 mg/day and 6-12 yr: 150 mg/day. |
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| Oral |
| TREATMENT OF NAUSEA AND VERTIGO CAUSE BY MENIERE'S DISEASE |
| Adult:
50-100 mg 3-4 times daily. |
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| Oral |
| TREATMENT OF NAUSEA AND VERTIGO CAUSE BY MENIERE'S DISEASE |
| Child:
6-12 yr: 25-50 mg; 2-6 yr: 12.5-25 mg. Doses can be given every 6-8 hr. Max: 2-6 yr: 75 mg/day and 6-12 yr: 150 mg/day. |
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| Parenteral |
| PREVENTION AND TREATMENT OF MOTION SICKNESS |
| Adult:
50 mg in a 5% solution given IM or 0.5% slow IV inj given over 2 min |
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| Parenteral |
| PREVENTION AND TREATMENT OF MOTION SICKNESS |
| Child:
1.25 mg/kg IM or slow IV inj 4 times daily. Max: 300 mg/day |
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| Parenteral |
| TREATMENT OF NAUSEA AND VERTIGO CAUSE BY MENIERE'S DISEASE |
| Adult:
50 mg in a 5% solution given IM or 0.5% slow IV inj given over 2 min |
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| Parenteral |
| TREATMENT OF NAUSEA AND VERTIGO CAUSE BY MENIERE'S DISEASE |
| Child:
1.25 mg/kg IM or slow IV inj 4 times daily. Max: 300 mg/day |
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| Administration |
May be taken with or without food. |
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| Precautions |
Angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction, epilepsy. Elderly. Tasks requiring mental alertness. Pregnancy. |
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| Adverse Drug Reactions |
Sedation, dry mouth, thickened respiratory tract secretions, tightness of chest, bradycardia followed by tachycardia and arrhythmias, blurred vision, urinary retention, constipation, GI disturbance, blood dyscrasias. Paradoxical CNS stimulation may occur in children and occasionally in adults. |
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| Interactions |
Potentiates the sedative effects of CNS depressants including alcohol, barbiturates, opioid analgesics, sedatives and neuroleptics. MAOIs, atropine, TCAs enhance antimuscarinic effect. Masks ototoxicity produced by aminoglycoside antibiotics. Physically incompatible with aminophylline, hydrocortisone, phenothiazines and some barbiturates in solution. |
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