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Indication & Dosage |
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| Oral |
| ADJUNCTIVE TREATMENT FOR CHRONIC ALCOHOLISM |
| Adult:
800 mg as a single dose on the 1st day of treatment, reduce dose by 200 mg daily. Maintenance: 100-200 mg daily. |
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| Administration |
May be taken with or without food. |
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| Precautions |
Diabetes, epilepsy, hepatic/renal impairment, hypothyroidism, cerebral damage, elderly. Liver function and blood tests should be monitored regularly. Pregnancy and lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Drowsiness, fatigue, lassitude, psychotic reactions, peripheral and optic neuropathies, hepatotoxicity, garlic-like or metallic after-taste, GI upset, body odour, bad breath, headache, impotence. |
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| Adverse Drug Reactions |
Respiratory depression, CV collapse, arrhythmias, myocardial infarction, acute CHF, convulsions, sudden death. |
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| Interactions |
Inhibits hepatic enzymes thus interferes with metabolism of other drugs; enhances anticoagulant effects of phenytoin and coumarin. Adverse CNS effects may be precipitated with concurrent metronidazole, INH or MAOI therapy. Tricyclic antidepressants exacerbate symptoms of disulfiram alcohol reaction. |
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