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Indication & Dosage |
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| Intravenous |
| MANAGEMENT OF ACUTE HEART FAILURE |
| Adult:
2.5-10 mcg/kg, up to 0.5-40 mcg/kg according to patient's heart rate, cardiac output, BP and urine output. |
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| Intravenous |
| CARDIAC STRESS TEST |
| Adult:
5 mcg/kg/min for 8 min using a 1 mg/ml solution, dose is then increased at 5 mcg/kg/min until 20 mcg/kg/min, with each dose being infused for 8 min before the next increase. Monitor ECG and stop infusion if arrhythmias, marked ST segment depression or other adverse effects occur |
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| Precautions |
Correct hypovolaemia prior to treatment. Increased risk of rapid ventricular response in patients with atrial fibrillation. Insufficient data to determine the safety and efficacy of dobutamine use after acute MI. Elderly. Neonates. Pregnancy. |
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Potentially Life-threatening
Adverse Drug Reactions |
Increased heart rate and BP, ectopic beats, palpitation. Nausea, headache, chest pain, palpitation, dyspnoea, paraesthesia, leg cramps. Tissue necrosis at site of extravasation. |
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| Adverse Drug Reactions |
Cardiac arrhythmias, allergy (rare), MI and hypotension. |
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| Interactions |
Increased cardiac output when used with nitroprusside. Increased vasopressor effect of dobutamine when used with bretylium, guanethidine, oxytocic drugs or TCAs. |
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