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Indication & Dosage |
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| Intravenous |
| PROSTATIC CANCER |
| Adult:
5 mg/m2 BSA once every 3 wk. For gastric adenocarcinoma: Dose is given before cisplatin and fluorouracil. For head and neck cancer: Treatment is given for 3 cycles followed by chemoradiotherapy or 4 wk followed by radiotherapy alone. For prostatic cancer: May be given with oral prednisolone 5 mg bid continuously during treatment. |
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| Intravenous |
| BREAST CANCER |
| Adult:
As a single agent: Initially, 60-100 mg/m2 BSA by infusion once every 3 wk. In combination therapy: 75 mg/m2 once every 3 wk. |
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| Intravenous |
| HEAD AND NECK CANCER |
| Adult:
75 mg/m2 BSA once every 3 wk. For gastric adenocarcinoma: Dose is given before cisplatin and fluorouracil. For head and neck cancer: Treatment is given for 3 cycles followed by chemoradiotherapy or 4 wk followed by radiotherapy alone. For prostatic cancer: May be given with oral prednisolone 5 mg bid continuously during treatment. |
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| Intravenous |
| NON-SMALL CELL LUNG CANCER |
| Adult:
75 mg/m2 BSA once every 3 wk. For gastric adenocarcinoma: Dose is given before cisplatin and fluorouracil. For head and neck cancer: Treatment is given for 3 cycles followed by chemoradiotherapy or 4 wk followed by radiotherapy alone. For prostatic cancer: May be given with oral prednisolone 5 mg bid continuously during treatment. |
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| Intravenous |
| GASTRIC ADENOCARCINOMA |
| Adult:
75 mg/m2 BSA once every 3 wk. For gastric adenocarcinoma: Dose is given before cisplatin and fluorouracil. For head and neck cancer: Treatment is given for 3 cycles followed by chemoradiotherapy or 4 wk followed by radiotherapy alone. For prostatic cancer: May be given with oral prednisolone 5 mg bid continuously during treatment. |
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| Precautions |
Lactation. Hepatic impairment. Monitor liver blood function and blood counts regularly. Premedication with oral dexamethsaone at 16 mg daily for 3 days, starting one day before docetaxel treatment is recommended. |
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Potentially Life-threatening
Adverse Drug Reactions |
Erythematous patches, eruptions, scleroderma, onycholysis, alopoecia, nausea, vomiting, diarrhoea, stomatitis; increases in hepatic transaminases, bilirubin and alkaline phosphatase; mucositis, asthenia, arthralgia, myalgia, paroxysmal atrial tachycardia, atrial flutter, dysrrhythmia, hypertension and heart failure. |
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| Adverse Drug Reactions |
Neutropenia; fluid retention syndrome; anaemia. |
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| Interactions |
Co-admin of drugs that induce, inhibit, or metabolised by cytochrome P-450 isoenzyme may affect the metabolism of docetaxel. |
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