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Indication & Dosage |
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| Oral |
| TREATMENT OF DEPRESSION |
| Adult:
Initially, 25 mg tid, gradually increased to 50 mg tid if necessary, alternatively as a single dose at night.
Elderly: 50-75 mg daily. |
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| Administration |
May be taken with or without food. |
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| Precautions |
Epilepsy, hypertension, glaucoma, urinary retention, gradual withdrawal, pregnancy, lactation, elderly. |
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Potentially Life-threatening
Adverse Drug Reactions |
Cholestatic jaundice, sexual dysfunction, exacerbation of psychotic manifestation, cardiac arrhythmias, hypotension, dry mouth, constipation, disturbance of accommodation, tachycardia, postural hypotension, drowsiness, tremors and skin rash. Withdrawal symptoms with abrupt cessation: Insomnia, irritability and excessive sweating. |
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| Adverse Drug Reactions |
Bone marrow depression, cardiac arrhythmias and agranulocytosis, reports of ventricular fibrillation and renal failure. |
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| Interactions |
Should not be given concurrently or within 14 days of stopping MAOIs. Potentiates catecholamines, sympathomimetics, narcotics and alcohol. Reduces hypotensive activity of bethanidine, guanethidine. |
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