 |
Indication & Dosage |
| |
| |
| Intravenous |
| OVARIAN CARCINOMA |
| Adult:
As pegylated liposome: 50 mg/m2 BSA infused over 1 hr once every 4 wk. |
| |
| Intravenous |
| AIDS-RELATED KAPOSI'S SARCOMA |
| Adult:
As pegylated liposome: 20 mg/m2 BSA infused over 30 min once every 2-3 wk. |
| |
| Intravenous |
| METASTATIC BREAST CARCINOMA |
| Adult:
60-75 mg/m2 BSA once every 3 wk in combination with cyclophosphamide given as an infusion over 1 hr diluted in 0.9% sodium chloride or 5% glucose. |
| |
| Irrigation |
| LOCAL MALIGNANT NEOPLASMS IN THE BLADDER |
| Adult:
50 ml of a 1 mg/ml solution instilled into the bladder for 1 hr once a mth. |
|
| |
|
| Precautions |
Elderly, children, hepatic impairment. Monitor blood counts and ECG. |
| |
|
Potentially Life-threatening
Adverse Drug Reactions |
Leucopenia, thrombocytopenia, nausea, vomiting, diarrhoea. Rarely facial flushing, rash, alopecia. Blurred vision, headache, seizures, paraesthesia, confusion, malaise, lethargy, skin pigmentation. |
| |
|
| Adverse Drug Reactions |
Bone marrow suppression, cardiotoxicity. |
| |
|
| Interactions |
Doxorubicin interacts with a number of other drugs e.g. antibiotics (aminoglycosides), steroids, aminophylline and propranolol. |
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