Indication & Dosage |
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| Oral |
| SUSCEPTIBLE INFECTIONS |
| Child:
>8 yr and <45 kg: Initially, 4 mg/kg in 2 divided doses followed by 2 mg/kg daily. |
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| Oral |
| SUSCEPTIBLE INFECTIONS |
| Adult:
200 mg on day 1 followed by 100 mg once daily. Maintain initial dose in severe infections. |
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| Oral |
| SENSITIVE GONOCOCCAL INFECTIONS |
| Adult:
100 mg bid for 7 days or a single dose of 300 mg followed by another dose repeated 1 hr later. |
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| Oral |
| SYPHILIS |
| Adult:
200 or 400 mg daily in divided doses for 10-15 days. |
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| Oral |
| RELAPSING FEVER AND LOUSE-BORNE TYPHUS |
| Adult:
200 mg on day 1 followed by 100 mg once daily. Maintain initial dose in severe infections. |
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| Oral |
| PROPHYLAXIS OF SCRUB TYPHUS |
| Adult:
200 mg on day 1 followed by 100 mg once daily. Maintain initial dose in severe infections. |
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| Oral |
| ACNE |
| Adult:
200 mg on day 1 followed by 100 mg once daily. Maintain initial dose in severe infections. |
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| Intravenous |
| SUSCEPTIBLE INFECTIONS |
| Adult:
200 mg on day 1 followed by 100 mg once daily. Maintain initial dose in severe infections. |
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| Administration |
Should be taken with food. (Take w/ a full glass of water & remain upright for at least ½ hr. Avoid taking w/ dairy products.) |
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| Precautions |
Impaired hepatic function; history or predisposition to oral candidiasis. Should be taken with at least a glass of water in an upright position to reduce the risk of oesophageal injury. |
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Potentially Life-threatening
Adverse Drug Reactions |
Permanent staining of teeth; rash, superinfection; nausea, GI upsets, glossitis; dysphagia; photosensitivity, hypersensitivity; haemolytic anaemia, thrombocytopenia, neutropenia and eosinophilia. |
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| Adverse Drug Reactions |
Anaphylaxis |
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| Interactions |
Reduction in absorption and bioavailability when used with antacids, calcium, magnesium and iron. Chronic ethanol ingestion reduces serum concentrations. Metabolism increased by hepatic enzyme inducers such as rifampicin, phenytoin and carbamazepine. May reduce the efficacy of oral contraceptives. |
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