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Indication & Dosage |
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| Oral |
| HIV INFECTION COMBINED WITH OTHER ANTIRETROVIRALS |
| Adult:
>3 yr, 10-14 kg: 200 mg; 15-19 kg: 250 mg; 20-24 kg: 300 mg; 25-32.4 kg: 350 mg; 32.5-39 kg: 400 mg; ≥40 kg: 600 mg. To be taken once daily. |
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| Oral |
| HIV INFECTION COMBINED WITH OTHER ANTIRETROVIRALS |
| Adult:
600 mg once daily. Dosing at bedtime recommended during 1st 2-4 wk of therapy to improve tolerability. |
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| Administration |
Stocrin®: May be taken with or without food.
Sustiva®: Should be taken on an empty stomach (i.e. At least one hour before food or four hours after food). (Take on an empty stomach, preferably at bedtime.) |
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| Precautions |
Mild to moderate liver disease; renal impairment. Monitor liver enzymes and cholesterol. Discontinue if severe skin rash or fever develops; known or suspected hepatitis B or infection. History of mental illness or seizures; elderly. Pregnancy. Children. |
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| Adverse Drug Reactions |
Rash including Stevens-Johnson syndrome and erythema multiforme; CNS effects e.g. dizziness, headache, insomnia, somnolence, abnormal dreams, fatigue, impaired concentration. Nausea, less frequently, vomiting, diarrhoea, hepatitis, depression, anxiety, psychosis, amnesia and ataxia, stupor, vertigo, abdominal pain, hepatic failure, pancreatitis, convulsions, gynaecomastia, pruritus, blurred vision. |
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| Interactions |
Hormonal contraceptives; antibacterial e.g. rifampicin, rifabutin, clarithromycin; enzyme inducers. St. John''s wort may decrease serum level. Ethanol (hepatic and CNS adverse effects). |
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